2641899-38-7

2641899-38-7 structure

Name: FD274
Chemical Name: FD274
CAS Number: 2641899-38-7
Molecular Formula: C₂₂H₁₄ClFN₆O₂S
Molecular Weight: 480.90
Catalog: Signaling Pathways PI3K/Akt/mTOR mTOR
Create Date: 2023-10-20 09:49:54
Modify Date: 2024-01-06 13:45:50
FD274 is a highly potent PI3K/mTOR dual inhibitor with IC50s of 0.65 nM, 1.57 nM, 0.65 nM, 0.42 nM, and 2.03 nM against PI3Kα/β/γ/δ and mTOR, respectively. FD274 exhibits significant anti-proliferation of AML cell lines (HL-60 and MOLM-16). FD274 demonstrates dose-dependent inhibition of tumor growth in the HL-60 xenograft model. FD274 has the potential for acute myeloid leukemia research[1].

Name	FD274

Description	FD274 is a highly potent PI3K/mTOR dual inhibitor with IC50s of 0.65 nM, 1.57 nM, 0.65 nM, 0.42 nM, and 2.03 nM against PI3Kα/β/γ/δ and mTOR, respectively. FD274 exhibits significant anti-proliferation of AML cell lines (HL-60 and MOLM-16). FD274 demonstrates dose-dependent inhibition of tumor growth in the HL-60 xenograft model. FD274 has the potential for acute myeloid leukemia research[1].
Related Catalog	Signaling Pathways >> PI3K/Akt/mTOR >> mTOR Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> PI3K
Target	PI3Kα:0.65 nM (IC50) PI3Kβ:1.57 nM (IC50) PI3Kδ:0.65 nM (IC50) PI3Kγ:0.42 nM (IC50) mTOR:2.03 nM (IC50)
References	[1]. Chengbin Yang, et al. Discovery of N-(2-chloro-5-(3-(pyridin-4-yl)-1H-pyrazolo[3,4-b]pyridin-5-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide (FD274) as a highly potent PI3K/mTOR dual inhibitor for the treatment of acute myeloid leukemia. Eur J Med Chem. 2023 Oct 5;258:115543.

Molecular Formula	C₂₂H₁₄ClFN₆O₂S
Molecular Weight	480.90