PAD4-IN-3

Modify Date: 2024-01-22 20:21:27

PAD4-IN-3 structure	Common Name	PAD4-IN-3
	CAS Number	2642327-44-2	Molecular Weight	444.72
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₁H₂₆BClN₄O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PAD4-IN-3

PAD4-IN-3 (compound 4B) is a PAD4 inhibitor with antitumor activity in vitro and in vivo. PAD4-IN-3 was covalently linked to RGD sequence peptide-modified chitosan (K-CRGDV), resulting in an enhanced oxidative stress-responsive nanoagent. K-CRGDV-PAD4-IN-3 can actively target tumors, inhibit PAD4 activity, block the formation of neutrophil extracellular traps (NETs), and improve the tumor immune microenvironment in response to the tumor microenvironment[1].

Name	PAD4-IN-3

Description	PAD4-IN-3 (compound 4B) is a PAD4 inhibitor with antitumor activity in vitro and in vivo. PAD4-IN-3 was covalently linked to RGD sequence peptide-modified chitosan (K-CRGDV), resulting in an enhanced oxidative stress-responsive nanoagent. K-CRGDV-PAD4-IN-3 can actively target tumors, inhibit PAD4 activity, block the formation of neutrophil extracellular traps (NETs), and improve the tumor immune microenvironment in response to the tumor microenvironment[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Protein Arginine Deiminase
Target	PAD4[1]
References	[1]. Jia Y et al. Chitosan nanomedicine containing RGD peptide and PAD4 inhibitor based on phenyl boronate coupling inhibition of primary tumor growth and lung metastasis. Biomed Pharmacother. 2023 Dec;168:115826.

Molecular Formula	C₂₁H₂₆BClN₄O₄
Molecular Weight	444.72

PAD4-IN-3

Use of PAD4-IN-3

Names

PAD4-IN-3 Biological Activity

Chemical & Physical Properties