RIPK3-IN-2

Modify Date: 2026-08-02 22:01:01

Use of RIPK3-IN-2

RIPK3-IN-2 is a RIP3 inhibitor. RIPK3-IN-2 can be used in diseases caused by or associate with activated necrotic pathways research[1].

Name	RIPK3-IN-2

Description	RIPK3-IN-2 is a RIP3 inhibitor. RIPK3-IN-2 can be used in diseases caused by or associate with activated necrotic pathways research[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Apoptosis >> RIP kinase
In Vitro	RIPK3-IN-2 (0.3-20 μM; 42 h) inhibits HT-29 cell growth[1]. RIPK3-IN-2 (0.3-20 μM; 14 h) inhibits MEF cell growth[1]. RIPK3-IN-2 (0.3-20 μM; 18 h) inhibits L929 cell growth[1]. Cell Viability Assay[1] Cell Line: HT-29 cells Concentration: 0.3, 1.0, 3.0, 10.0, 20.0 μM Incubation Time: 42 hours Result: Showed EC50 value of 0.085 μM. Cell Viability Assay[1] Cell Line: MEF cells Concentration: 0.3, 1.0, 3.0, 10.0, 20.0 μM Incubation Time: 14 hours Result: Showed EC50 value of 0.24 μM. Cell Viability Assay[1] Cell Line: L929 cells Concentration: 0.3, 1.0, 3.0, 10.0, 20.0 μM Incubation Time: 18 hours Result: Showed EC50 value of 0.21 μM.
References	[1]. Xiaohu Zhang, et al. Heteroaryl compounds as inhibitors of programmed necrosis pathway, composition and method using the same. WO2021138694A1

Molecular Formula	C₂₁H₁₆ClN₃O₂S₂
Molecular Weight	441.95
InChIKey	XLZJGOZHZJNQGS-UHFFFAOYSA-N
SMILES	Cl.O=S1(=O)C=C(C2CC2)c2cc3nccc(Nc4ccc5scnc5c4)c3cc21

Name: Inhibition of CYP1A2 (unknown origin) at 10 uM
Source: ChEMBL
Target: Cytochrome P450 1A2
External Id: CHEMBL5339924

Name: Inhibition of CYP2C9 (unknown origin) at 10 uM
Source: ChEMBL
Target: Cytochrome P450 2C9
External Id: CHEMBL5339925

Name: Inhibition of CYP3A4 (unknown origin) at 10 uM
Source: ChEMBL
Target: Cytochrome P450 3A4
External Id: CHEMBL5339922

Name: Inhibition of CYP2D6 (unknown origin) at 10 uM
Source: ChEMBL
Target: Cytochrome P450 2D6
External Id: CHEMBL5339923

Name: Volume of distribution in ICR mouse at 2 mg/kg, iv
Source: ChEMBL
Target: N/A
External Id: CHEMBL5339934

Name: Clearance in ICR mouse at 2 mg/kg, iv
Source: ChEMBL
Target: N/A
External Id: CHEMBL5339935

Name: Half life in ICR mouse at 2 mg/kg, iv
Source: ChEMBL
Target: N/A
External Id: CHEMBL5339932

Name: AUC in ICR mouse at 10 mg/kg, po
Source: ChEMBL
Target: N/A
External Id: CHEMBL5339933

Name: Metabolic stability in mouse liver microsomes assessed as half life
Source: ChEMBL
Target: N/A
External Id: CHEMBL5339930

Name: Metabolic stability in rat liver microsomes assessed as half life
Source: ChEMBL
Target: N/A
External Id: CHEMBL5339931

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