Isoflurane

Modify Date: 2026-07-01 20:37:04

Isoflurane structure	Common Name	Isoflurane
	CAS Number	26675-46-7	Molecular Weight	184.492
	Density	1.5±0.1 g/cm3	Boiling Point	48.5±0.0 °C at 760 mmHg
	Molecular Formula	C₃H₂ClF₅O	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	-10.6±25.9 °C
	Symbol	GHS07, GHS08	Signal Word	Warning

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	isoflurane
Synonym	More Synonyms

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.5±0.1 g/cm3
Boiling Point	48.5±0.0 °C at 760 mmHg
Molecular Formula	C₃H₂ClF₅O
Molecular Weight	184.492
Flash Point	-10.6±25.9 °C
Exact Mass	183.971436
PSA	9.23000
LogP	2.33
Vapour Pressure	323.0±0.0 mmHg at 25°C
Index of Refraction	1.301
InChIKey	PIWKPBJCKXDKJR-UHFFFAOYSA-N
SMILES	FC(F)OC(Cl)C(F)(F)F
Stability	Stable.

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

Isoflurane MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KN6799000

CHEMICAL NAME :: Ether, 1-chloro-2,2,2-trifluoroethyl difluoromethyl

CAS REGISTRY NUMBER :: 26675-46-7

LAST UPDATED :: 199612

DATA ITEMS CITED :: 17

MOLECULAR FORMULA :: C3-H2-Cl-F5-O

MOLECULAR WEIGHT :: 184.50

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4770 uL/kg

TOXIC EFFECTS :: Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,3031,1987

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 15300 ppm/3H

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - excitement Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,3031,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4280 uL/kg

TOXIC EFFECTS :: Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,3031,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5080 uL/kg

TOXIC EFFECTS :: Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,3031,1987

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 16800 ppm/3H

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - excitement Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,3031,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3030 uL/kg

TOXIC EFFECTS :: Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,3031,1987 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 12000 ppm/3H/10W-I

TOXIC EFFECTS :: Endocrine - changes in adrenal weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Related to Chronic Data - death

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,3037,1987

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 150 ppm/24H/5W-C

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1940- Volume(issue)/page/year: 42,408,1975

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1500 ppm/24H/5W-C

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1940- Volume(issue)/page/year: 42,408,1975 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 10500 ppm/6H

SEX/DURATION :: female 14-16 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1940- Volume(issue)/page/year: 64,339,1986

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 4000 ppm/3H

SEX/DURATION :: female 7-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,3091,1987

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 12000 ppm/3H

SEX/DURATION :: female 17-20 day(s) after conception lactating female 21 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - physical

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,3109,1987

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 6000 ppm/4H

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 29(2),54A,1984 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,93,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3787 No. of Facilities: 1009 (estimated) No. of Industries: 2 No. of Occupations: 7 No. of Employees: 33152 (estimated) No. of Female Employees: 27151 (estimated)

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol	GHS07, GHS08
Signal Word	Warning
Hazard Statements	H336-H373
Precautionary Statements	P260
Target Organs	Cardio-vascular system, Central nervous system
Hazard Codes	F,T
Risk Phrases	R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases	S26-S36/37/39
RIDADR	UN 3334
RTECS	KN6799000
HS Code	3004909030

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

1,1-dichloro-1-...

CAS#:32778-07-7

~96%

Isoflurane

CAS#:26675-46-7

Learn More

Literature: Journal of Fluorine Chemistry, , vol. 80, # 2 p. 101 - 104

1-Chlor-2,2,2-t...

CAS#:26644-88-2

Isoflurane

CAS#:26675-46-7

Learn More

Literature: Journal of medicinal chemistry, , vol. 15, # 6 p. 604 - 606

difluoromethyl ...

CAS#:1885-48-9

Isoflurane

CAS#:26675-46-7

Learn More

Literature: Journal of medicinal chemistry, , vol. 14, # 6 p. 517 - 519

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 3
CAS#:32778-07-7 1,1-dichloro-1-... CAS#:26644-88-2 1-Chlor-2,2,2-t... CAS#:1885-48-9 difluoromethyl ...
DownStream 1
CAS#:57041-67-5 Desflurane

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2909199090
Summary	2909199090. other acyclic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

This table lists relevant public references with title, journal and publication metadata for this compound.

Imaging of a clinically relevant stroke model: glucose hypermetabolism revisited.

Stroke 46(3) , 835-42, (2015)

Ischemic stroke has been shown to cause hypermetabolism of glucose in the ischemic penumbra. Experimental and clinical data indicate that infarct-related systemic hyperglycemia is a potential therapeu...

Suppression of the HSF1-mediated proteotoxic stress response by the metabolic stress sensor AMPK.

EMBO J. 34(3) , 275-93, (2015)

Numerous extrinsic and intrinsic insults trigger the HSF1-mediated proteotoxic stress response (PSR), an ancient transcriptional program that is essential to proteostasis and survival under such condi...

Detailed characterization of a long-term rodent model of critical illness and recovery.

Crit. Care Med. 43(3) , e84-96, (2015)

To characterize a long-term model of recovery from critical illness, with particular emphasis on cardiorespiratory, metabolic, and muscle function.Randomized controlled animal study.University researc...

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273

Name: Rat K2P3.1 (Two P domain potassium channels)
Source: IUPHAR-DB
Target: K2P3.1 (Two P domain potassium channels) [Rattus norvegicus]
External Id: 515_Rat

Name: p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree...
Source: 824
Target: N/A
External Id: P53600

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce...
Source: 824
Target: N/A
External Id: P53MS958

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary
Source: 824
External Id: P53MS482

Name: p53 small molecule agonists, cell-based qHTS assay
Source: 824
External Id: P53344

Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS233

Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes: qHTS ...
Source: 824
Target: N/A
External Id: P53MS837

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS898

Name: qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity
Source: NCGC
External Id: HERG01

Total 280, Current Page 1 of 28

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

2-chloro-2-(difluoromethoxy)-1,1,1-trifluoro-ethane

Isoflurano

1-Chloro-2,2,2-trifluoroethyl difluoromethyl ether

Forane

Compd 469

Isoflurane

1-Chlor-2,2,2-trifluorethyl-difluormethylether

2-(difluoromethoxy)-1,1,1-trifluoro-2-chloroethane

2-Chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane

MFCD00066609

Forene

EINECS 247-897-7

Isofluranum

Compound 469

IsoFlo

Aerrane

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the boiling point of isoflurane?

A: Boiling point of isoflurane is 48.5±0.0 °C at 760 mmHg.

Q: What is the polar surface area (PSA) of isoflurane?

A: Polar surface area (PSA) of isoflurane is 9.23000.

Q: What is the LogP of isoflurane?

A: LogP of isoflurane is 2.33.

Q: What is the InChIKey of isoflurane?

A: InChIKey of isoflurane is PIWKPBJCKXDKJR-UHFFFAOYSA-N.

Q: What English synonyms does isoflurane have?

A: English synonyms of isoflurane: 2-chloro-2-(difluoromethoxy)-1,1,1-trifluoro-ethane, Isoflurano, 1-Chloro-2,2,2-trifluoroethyl difluoromethyl ether, Forane, Compd 469, Isoflurane, 1-Chlor-2,2,2-trifluorethyl-difluormethylether, 2-(difluoromethoxy)-1,1,1-trifluoro-2-chloroethane, 2-Chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane, MFCD00066609, Forene, EINECS 247-897-7, Isofluranum, Compound 469, IsoFlo, Aerrane.

Q: What are the upstream materials of isoflurane?

A: Related upstream materials(CAS) of isoflurane: 32778-07-7;26644-88-2;1885-48-9.

Q: What is the English name of isoflurane?

A: The English name of isoflurane is isoflurane.

Q: What are the downstream products of isoflurane?

A: Related downstream products(CAS) of isoflurane: 57041-67-5.

Q: What is the molecular weight of isoflurane?

A: Molecular weight of isoflurane is 184.492.

Q: What is the SMILES notation of isoflurane?

A: SMILES notation of isoflurane is FC(F)OC(Cl)C(F)(F)F.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Henan Tianfu Chemical Co., Ltd.

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Isoflurane
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Isoflurane
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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Isoflurane

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