JPS014

Modify Date: 2024-04-05 13:29:34

JPS014 structure	Common Name	JPS014
	CAS Number	2669785-76-4	Molecular Weight	854.07
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₄₆H₅₉N₇O₇S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of JPS014

JPS014 is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC). JPS014 degrades class I histone deacetylase (HDAC). JPS014 is potent HDAC1/2 degrader correlated with greater total differentially expressed genes and enhanced apoptosis in HCT116 cells[1].

Name	JPS014

Description	JPS014 is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC). JPS014 degrades class I histone deacetylase (HDAC). JPS014 is potent HDAC1/2 degrader correlated with greater total differentially expressed genes and enhanced apoptosis in HCT116 cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> PROTAC >> PROTAC Signaling Pathways >> Epigenetics >> HDAC
References	[1]. Smalley JP, et al. Optimization of Class I Histone Deacetylase PROTACs Reveals that HDAC1/2 Degradation is Critical to Induce Apoptosis and Cell Arrest in Cancer Cells. J Med Chem. 2022;65(7):5642-5659.

Molecular Formula	C₄₆H₅₉N₇O₇S
Molecular Weight	854.07

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: JPS014
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: JPS014
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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