Perivine

Modify Date: 2024-01-10 20:27:00

Perivine structure	Common Name	Perivine
	CAS Number	2673-40-7	Molecular Weight	338.400
	Density	1.3±0.1 g/cm3	Boiling Point	541.1±50.0 °C at 760 mmHg
	Molecular Formula	C₂₀H₂₂N₂O₃	Melting Point	180-181ºC
	MSDS	N/A	Flash Point	281.0±30.1 °C

Use of Perivine

Perivine (Perivin) targets protein retinoblastoma-associated proteins (RbAp48) and resolves the instability of the RbAp48-FOG-1 complex. Perivine can be used for the study of Alzheimer's disease[1].

Name	Perivine
Synonym	More Synonyms

Description	Perivine (Perivin) targets protein retinoblastoma-associated proteins (RbAp48) and resolves the instability of the RbAp48-FOG-1 complex. Perivine can be used for the study of Alzheimer's disease[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
Target	IC50: Retinoblastoma-associated proteins (RbAp48)[1]
In Vitro	Retinoblastoma-associated proteins (RbAp48) are related to Alzheimer's disease (AD), RbAp48 forms a complex with the peptide FOG-1 (friend of GATA-1) and has a role in gene transcription. However, this is an unstable complex may affect the function of RbAp48. Perivine has a greater stable affinity for RbAp48 binding than FOG1, it might resolve the instability of the RbAp48-FOG1 complex and thus be used in AD therapy[1].
References	[1]. Hung-Jin Huang, et al. Lead Discovery for Alzheimer's Disease Related Target Protein RbAp48 From Traditional Chinese Medicine. Biomed Res Int

Density	1.3±0.1 g/cm3
Boiling Point	541.1±50.0 °C at 760 mmHg
Melting Point	180-181ºC
Molecular Formula	C₂₀H₂₂N₂O₃
Molecular Weight	338.400
Flash Point	281.0±30.1 °C
Exact Mass	338.163055
PSA	71.19000
LogP	3.53
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.652

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ZB1740000

CHEMICAL NAME :: Vobasan-17-oic acid, 4-demethyl-3-oxo-, methyl ester

CAS REGISTRY NUMBER :: 2673-40-7

BEILSTEIN REFERENCE NO. :: 0046952

LAST UPDATED :: 199707

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C20-H22-N2-O3

MOLECULAR WEIGHT :: 338.44

WISWESSER LINE NOTATION :: T E6 D586 A KM NV PY RM&&TTJ AVO1 PU2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

REFERENCE :: 33GVAL "Catharanthus Alkaloids," Taylor, W.I., and N.R. Farnsworth, eds., New York, Marcel Dekker, 1975 Volume(issue)/page/year: -,73,1975

Hazard Codes	Xi

2,6-Methano-1H-azecino[5,4-b]indole-14-carboxylic acid, 5-ethylidene-2,3,4,5,6,7,8,9-octahydro-8-oxo-, methyl ester, (2S,5E,6R,14S)-

2,6-methano-1H-azecino[5,4-b]indole-14-carboxylic acid, 5-ethylidene-2,3,4,5,6,7,8,9-octahydro-8-oxo-, methyl ester, (2S,5E,6R)-

3-oxo-22-nor-vobasan-17-oic acid methyl ester

X1201

Methyl (1S,14R,15E,18S)-15-ethylidene-12-oxo-10,17-diazatetracyclo[12.3.1.0.0]octadeca-3(11),4,6,8-tetraene-18-carboxylate

Methyl (1S,14R,15E)-15-ethylidene-12-oxo-10,17-diazatetracyclo[12.3.1.0.0]octadeca-3(11),4,6,8-tetraene-18-carboxylate

Vobasan-17-oic acid,4-demethyl-3-oxo-,methyl ester

Perivin

3-Oxo-22-nor-vobasan-17-saeure-methylester

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Perivine
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Perivine
Price: ￥1378.0/20mg
Purity: 98.0%
Delivery: 2 Day
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: Perivine
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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Perivine

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