G2019S-LRRK2 inhibitor 38
Modify Date: 2024-01-20 16:42:42
G2019S-LRRK2 inhibitor 38 structure
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Common Name | G2019S-LRRK2 inhibitor 38 | ||
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| CAS Number | 2704564-03-2 | Molecular Weight | 379.467 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H21N5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of G2019S-LRRK2 inhibitor 38G2019S-LRRK2 inhibitor 38 is a potent, selective, brain penetrant G2019S-LRRK2 kinase inhibitor with IC50 of <1 nM, cellular EC50 of 40 nM, >2,000-fold selectivity over WT LRRK2 (cellular EC50>100 uM).G2019S-LRRK2 inhibitor 38 selectively inhibit phosphorylation of Ser935 in vitro, and in brain, lung, kidney and spleen in G2019S-LRRK2 mice. |
| Name | G2019S-LRRK2 inhibitor 38 |
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| Description | G2019S-LRRK2 inhibitor 38 is a potent, selective, brain penetrant G2019S-LRRK2 kinase inhibitor with IC50 of <1 nM, cellular EC50 of 40 nM, >2,000-fold selectivity over WT LRRK2 (cellular EC50>100 uM).G2019S-LRRK2 inhibitor 38 selectively inhibit phosphorylation of Ser935 in vitro, and in brain, lung, kidney and spleen in G2019S-LRRK2 mice. |
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| References | 1. Robert K Leśniak, et al. Eur J Med Chem. 2022 Feb 5;229:114080. |
| Molecular Formula | C24H21N5 |
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| Molecular Weight | 379.467 |