Antiproliferative agent-30

Modify Date: 2024-02-08 10:48:43

Antiproliferative agent-30 Structure
Antiproliferative agent-30 structure
Common Name Antiproliferative agent-30
CAS Number 2713553-88-7 Molecular Weight 434.49
Density N/A Boiling Point N/A
Molecular Formula C24H26N4O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Antiproliferative agent-30


Antiproliferative agent-30 (Compound 8g) inhibits tubulin assembly and inhibits FLT3 and Abl1. Antiproliferative agent-30 has vascular-disrupting activity. Antiproliferative agent-30 has broad antiproliferative activities against cancer cell lines (IC50s: 0.054 nM, 0.008 nM, 0.144 nM for HCT-116, K562, MV-4-11 cells respectively). Antiproliferative agent-30 also has anticancer effect against AML with FLT3-ITD-TKD mutation[1].

 Names

Name Antiproliferative agent-30

 Antiproliferative agent-30 Biological Activity

Description Antiproliferative agent-30 (Compound 8g) inhibits tubulin assembly and inhibits FLT3 and Abl1. Antiproliferative agent-30 has vascular-disrupting activity. Antiproliferative agent-30 has broad antiproliferative activities against cancer cell lines (IC50s: 0.054 nM, 0.008 nM, 0.144 nM for HCT-116, K562, MV-4-11 cells respectively). Antiproliferative agent-30 also has anticancer effect against AML with FLT3-ITD-TKD mutation[1].
Related Catalog
References

[1]. Chengqing Ning, et al. Design, synthesis, and biological evaluation of 3, 5-disubsituted-1H-pyrazolo[3,4-b]pyridines as multiacting inhibitors against microtubule and kinases. European Journal of Medicinal Chemistry. Volume 259, 5 November 2023, 115687.

 Chemical & Physical Properties

Molecular Formula C24H26N4O4
Molecular Weight 434.49
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