SKLB-197

Modify Date: 2025-08-25 21:35:22

SKLB-197 Structure
SKLB-197 structure
 Common Name SKLB-197
CAS Number 2713577-16-1 Molecular Weight 424.50
Density N/A Boiling Point N/A
Molecular Formula C25H24N6O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of SKLB-197


SKLB-197 showed an IC50 value of 0.013 μM against ATR but very weak or no activity against other 402 protein kinases. It displayed potent antitumor activity against ATM-deficent tumors both in vitro and in vivo.

 Names

Name SKLB-197

 SKLB-197 Biological Activity

Description SKLB-197 showed an IC50 value of 0.013 μM against ATR but very weak or no activity against other 402 protein kinases. It displayed potent antitumor activity against ATM-deficent tumors both in vitro and in vivo.
Related Catalog
Target

ATR:0.013 μM (IC50)

References

[1]. Bin H,et al. Discovery of a potent and highly selective inhibitor of ataxia telangiectasia mutated and Rad3-Related (ATR) kinase: Structural activity relationship and antitumor activity both in vitro and in vivo. Eur J Med Chem. 2022 Feb 12;232:114187

 Chemical & Physical Properties

Molecular Formula C25H24N6O
Molecular Weight 424.50
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Chemsrc provides SKLB-197(CAS#:2713577-16-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of SKLB-197 are included as well.>> amp version: SKLB-197

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