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  • DC Chemicals Limited
  • China
  • Product Name: SKLB-197
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

2713577-16-1

2713577-16-1 structure
2713577-16-1 structure
  • Name: SKLB-197
  • Chemical Name: SKLB-197
  • CAS Number: 2713577-16-1
  • Molecular Formula: C25H24N6O
  • Molecular Weight: 424.50
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage ATM/ATR
  • Create Date: 2022-03-22 21:43:37
  • Modify Date: 2024-01-12 10:33:49
  • SKLB-197 showed an IC50 value of 0.013 μM against ATR but very weak or no activity against other 402 protein kinases. It displayed potent antitumor activity against ATM-deficent tumors both in vitro and in vivo.

Name SKLB-197
Description SKLB-197 showed an IC50 value of 0.013 μM against ATR but very weak or no activity against other 402 protein kinases. It displayed potent antitumor activity against ATM-deficent tumors both in vitro and in vivo.
Related Catalog
Target

ATR:0.013 μM (IC50)

References

[1]. Bin H,et al. Discovery of a potent and highly selective inhibitor of ataxia telangiectasia mutated and Rad3-Related (ATR) kinase: Structural activity relationship and antitumor activity both in vitro and in vivo. Eur J Med Chem. 2022 Feb 12;232:114187

Molecular Formula C25H24N6O
Molecular Weight 424.50