AZ-5104-d2

Modify Date: 2024-04-05 18:49:44

AZ-5104-d2 structure	Common Name	AZ-5104-d2
	CAS Number	2719691-01-5	Molecular Weight	487.59
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₇H₂₉D₂N₇O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of AZ-5104-d2

AZ-5104-d2 is the deuterium labeled AZ-5104. AZ-5104 is an EGFR inhibitor with IC50s of 1 nM, 6 nM, 1 nM, 25 nM and 7 nM for EGFRL858R/T790M, EGFRL858R, EGFRL861Q, EGFR and ErbB4, respectively[1].

Name	AZ-5104-d2

Description	AZ-5104-d2 is the deuterium labeled AZ-5104. AZ-5104 is an EGFR inhibitor with IC50s of 1 nM, 6 nM, 1 nM, 25 nM and 7 nM for EGFRL858R/T790M, EGFRL858R, EGFRL861Q, EGFR and ErbB4, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
References	[1]. Cross DA, et al. AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer. Cancer Discov. 2014 Sep;4(9):1046-61.

Molecular Formula	C₂₇H₂₉D₂N₇O₂
Molecular Weight	487.59

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