Disitertide

Modify Date: 2024-01-06 12:24:17

Disitertide structure	Common Name	Disitertide
	CAS Number	272105-42-7	Molecular Weight	1580.82000
	Density	1.327g/cm3	Boiling Point	1968.718ºC at 760 mmHg
	Molecular Formula	C₆₈H₁₀₉N₁₇O₂₂S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Disitertide

Disitertide is an inhibitor of TGF-β1. Sequence: Thr-Ser-Leu-Asp-Ala-Ser-Ile-Ile-Trp-Ala-Met-Met-Gln-Asn.

Name	Disitertide
Synonym	More Synonyms

Description	Disitertide is an inhibitor of TGF-β1. Sequence: Thr-Ser-Leu-Asp-Ala-Ser-Ile-Ile-Trp-Ala-Met-Met-Gln-Asn.
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> TGF-beta/Smad Signaling Pathways >> TGF-beta/Smad >> TGF-beta/Smad Research Areas >> Cancer Peptides Peptides
In Vitro	Disitertide (P144) prevents TGF-β1-dependent inhibition of MV1Lu proliferation in vitro and markedly reduces binding of TGF-β1 to its receptors. Disitertide blocks TGF-β1-dependent stimulation of a reporter gene under the control of human α2(I) collagen promoter[1].
In Vivo	Treatment with Disitertide at low doses causes a significant inhibition of HSC activation and a marked reduction in liver fibrosis in a rat model of chronic exposure to CCl4. A dose as low as 70 μg of the 15-mer peptide Disitertide, given to rats (300 g body weight) on alternate days, decreases fibrogenesis significantly during chronic exposure to CCl4[1].
References	[1]. Ezquerro IJ et al. A synthetic peptide from transforming growth factor beta type III receptor inhibits liver fibrogenesis in rats with carbon tetrachloride liver injury. Cytokine. 2003 Apr;22(1-2):12-20.

Density	1.327g/cm3
Boiling Point	1968.718ºC at 760 mmHg
Molecular Formula	C₆₈H₁₀₉N₁₇O₂₂S₂
Molecular Weight	1580.82000
Exact Mass	1579.74000
PSA	692.18000
LogP	1.27260
Storage condition	-20°C

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DC Chemicals Limited
China
Product Name: Disitertide
Price: $352.0/5mg $600.0/10mg $1280.0/25mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Zhejiang Hangyu API Co., Ltd
China
Product Name: Disitertide
Price: $Inquiry/1kg
Purity: 99.0%
Stocking Period: 1 Day
Contact: Vinnie

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Price: $1565/10mM*1mLinDMSO

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