Econazole

Modify Date: 2024-01-02 18:55:37

Econazole Structure
Econazole structure
Common Name Econazole
CAS Number 27220-47-9 Molecular Weight 381.684
Density 1.3±0.1 g/cm3 Boiling Point 533.8±50.0 °C at 760 mmHg
Molecular Formula C18H15Cl3N2O Melting Point 86.8ºC
MSDS N/A Flash Point 276.6±30.1 °C

 Use of Econazole


Econazole is an antifungal compound of the imidazole class.

 Names

Name Econazole
Synonym More Synonyms

 Econazole Biological Activity

Description Econazole is an antifungal compound of the imidazole class.
Related Catalog
References

[1]. Thienpont D, et al. Bilogical and toxicological properties of econazole, a broad-spectrum antimycotic. Arzneimittelforschung. 1975 Feb;25(2):224-30.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 533.8±50.0 °C at 760 mmHg
Melting Point 86.8ºC
Molecular Formula C18H15Cl3N2O
Molecular Weight 381.684
Flash Point 276.6±30.1 °C
Exact Mass 380.024994
PSA 27.05000
LogP 5.32
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.615

 MSDS

Material Safety Data Sheet

Section1. Identification of the substance
Product Name: Econazole
Synonyms:1-[2-[(4-Chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole

Section2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

Section3. Composition/information on ingredients.
Ingredient name:Econazole
CAS number:27220-47-9

Section4. First aid measures
Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

Section5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

Section6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution:Wear approved mask/respirator
Hand precaution:Wear suitable gloves/gauntlets
Skin protection:Wear suitable protective clothing
Eye protection:Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

Section7. Handling and storage
Handling:This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

Section8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section9. Physical and chemical properties
Appearance:Not specified
Boiling point:No data
No data
Melting point:
Flash point:No data
Density:No data
Molecular formula:C18H15Cl3N2O
Molecular weight:381.7

Section10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen chloride.

Section11. Toxicological information
No data.

Section12. Ecological information
No data.

Section13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

Section14. Transportation information
Non-harzardous for air and ground transportation.

Section15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NI4767000
CHEMICAL NAME :
Imidazole, 1-(2,4-dichloro-beta-((p-chlorobenzyl)oxy)phenethyl)-
CAS REGISTRY NUMBER :
27220-47-9
BEILSTEIN REFERENCE NO. :
0964150
LAST UPDATED :
199612
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C18-H15-Cl3-N2-O
MOLECULAR WEIGHT :
381.70

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TEST SYSTEM :
Rodent - mouse
DOSE/DURATION :
80 mg/kg
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 4,208,1989

 Safety Information

Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases 24/25-36/37/39

 Articles31

More Articles
The use of ammonium hydroxide as an additive in supercritical fluid chromatography for achiral and chiral separations and purifications of small, basic medicinal molecules.

J. Chromatogr. A. 1218(43) , 7886-94, (2011)

This study describes using 0.1% of a 28-30% ammonium hydroxide solution as an additive to alcohol modifiers in SFC to improve chromatographic peak shapes for basic molecules. Ammonium hydroxide's high...

A method to identify and validate mitochondrial modulators using mammalian cells and the worm C. elegans.

Sci. Rep. 4 , 5285, (2014)

Mitochondria are semi-autonomous organelles regulated by a complex network of proteins that are vital for many cellular functions. Because mitochondrial modulators can impact many aspects of cellular ...

Effect of methoxychlor on Ca(2+) movement and viability in MDCK renal tubular cells.

Basic Clin Pharmacol Toxicol. 111(4) , 224-31, (2012)

The effect of the insecticide methoxychlor on the physiology of renal tubular cells is unknown. This study aimed to explore the effect of methoxychlor on cytosolic Ca(2+) concentrations ([Ca(2+) ](i) ...

 Synonyms

1-{2-[(4-Chlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
1-[2,4-Dichloro-b-[(p-chlorobenzyl)oxy]phenethyl]imidazole
1-[2-[(4-Chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
EINECS 248-341-6
Econazole
Ecostatin
Imidazole, 1-(2,4-dichloro-β-((p-chlorobenzyl)oxy)phenethyl)-
Gyno-Pevaryl
1H-Imidazole, 1-(2-((4-chlorophenyl)methoxy)-2-(2,4-dichlorophenyl)ethyl)-
UNII:6Z1Y2V4A7M
Spectazole
Palavale
1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}imidazole
Epi-pevaryl
Ifenec
econazolum
Pevaryl
1H-Imidazole, 1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-
MFCD00800993