Enpp-1-IN-19
Modify Date: 2024-01-01 13:33:37
Enpp-1-IN-19 structure
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Common Name | Enpp-1-IN-19 | ||
|---|---|---|---|---|
| CAS Number | 2738583-25-8 | Molecular Weight | 344.39 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H16N4O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Enpp-1-IN-19Enpp-1-IN-19 (compound 29f) is an orally active ENPP1 inhibitor that inhibits cGAMP hydrolysis by ENPP1 (IC50=68 nM). Enpp-1-IN-19 increases anti-PD-L1 responses and inhibits tumor growth in CT26 syngeneic models. Enpp-1-IN-19 also enhances STING-mediated type I interferon responses, induces immune memory, and prevents tumor recurrence[1]. |
| Name | Enpp-1-IN-19 |
|---|
| Description | Enpp-1-IN-19 (compound 29f) is an orally active ENPP1 inhibitor that inhibits cGAMP hydrolysis by ENPP1 (IC50=68 nM). Enpp-1-IN-19 increases anti-PD-L1 responses and inhibits tumor growth in CT26 syngeneic models. Enpp-1-IN-19 also enhances STING-mediated type I interferon responses, induces immune memory, and prevents tumor recurrence[1]. |
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| Related Catalog | |
| Target |
ENPP1[1] |
| References |
| Molecular Formula | C16H16N4O3S |
|---|---|
| Molecular Weight | 344.39 |