FXIa-IN-8
FXIa-IN-8 structure
|
Common Name | FXIa-IN-8 | ||
|---|---|---|---|---|
| CAS Number | 2744293-04-5 | Molecular Weight | 629.07 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C31H29ClN8O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of FXIa-IN-8FXIa-IN-8 is a potent and selective FXIa inhibitor with an IC50 of 14.2 nM. FXIa-IN-8 shows antithrombotic activity without increasing the bleeding risk and obvious toxicitysup>[1]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | FXIa-IN-8 |
|---|
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | FXIa-IN-8 is a potent and selective FXIa inhibitor with an IC50 of 14.2 nM. FXIa-IN-8 shows antithrombotic activity without increasing the bleeding risk and obvious toxicitysup>[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 14.2 nM (FXIa); 27900 nM (PKal)[1] |
| In Vitro | FXIa-IN-8 (compound 35) (0-250 µg/mL) shows significant anticoagulant activity toward the intrinsic pathway without affecting the extrinsic pathway[1]. |
| In Vivo | FXIa-IN-8 shows selectivity for FXIa and PKal with IC50s of 14.2, 27900 nM, respectively[1]. FXIa-IN-8 (6.5, 19.5 mg/kg; i.v.) shows antithrombotic activity in vivo[1]. FXIa-IN-8 (50, 100 mg/kg; i.v.) shows no acute toxicity[1]. FXIa-IN-8 (10 mg/kg; i.v.) shows moderate PK profiles[1].FXIa-IN-8 (19.5, 39 mg/kg) exhibits a much lower bleeding risk than heparin sodium at 300 IU/kg[1]. Pharmacokinetic Parameters of FXIa-IN-8 in Male SD rats[1]. compd 35 T1/2 (h) Cmax (µg/mL) AUC0-t (h·µg/mL) AUC0-∞ (h·µg/mL) Vz(mL/kg) Cl (mL/h/kg) MRT0-t (h) i.v. (10 mg/kg) 1.26 57 18.3 18.4 969 553 0.32Male SD rats; 10 mg/kg for i.v.[1]. Animal Model: Male SD rats[1] Dosage: 10 mg/kg (300 IU/kg (2.7 mg/kg) heparin sodium were injected into the tail vein 10 min before surgery) Administration: I.v. Result: Showed moderate PK profiles with a half-life value (T1/2) of 1.26 h and a clearance (Cl) value of 553 mL/h/kg. Animal Model: C57BL/6J mice (FeCl3-induced carotid artery thrombus model)[1] Dosage: 6.5, 19.5 mg/kg Administration: I.v. Result: Slightly prolonged the time of occlusion at 6.5 mg/kg, and showed excellent antithrombotic activity at 35 mg/kg. Animal Model: ICR mice[1] Dosage: 50, 100 mg/kg Administration: I.v. Result: Showed no obvious toxic reaction to different tissues of mice. Animal Model: C57BL/6J mice[1] Dosage: 19.5, 39, 20, 60, 100 mg/kg Administration: I.v. Result: Showed a low bleeding risk at 60 and 100 mg/kg. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Molecular Formula | C31H29ClN8O5 |
|---|---|
| Molecular Weight | 629.07 |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the molecular weight of FXIa-IN-8? |
| A: Molecular weight of FXIa-IN-8 is 629.07. |
| Q: What is the CAS number of FXIa-IN-8? |
| A: CAS number of FXIa-IN-8 is 2744293-04-5. |
| Q: What is the Chinese name of 2744293-04-5? |
| A: Chinese name of 2744293-04-5 is 2744293-04-5. |
| Q: What are the uses of FXIa-IN-8? |
| A: Main uses of FXIa-IN-8: FXIa-IN-8 is a potent and selective FXIa inhibitor with an IC50 of 14.2 nM. FXIa-IN-8 shows antithrombotic activity without increasing the bleeding risk and obvious toxicitysup>[1]. |
| Q: What is the molecular formula of FXIa-IN-8? |
| A: Molecular formula of FXIa-IN-8 is C31H29ClN8O5. |
| Q: What is the English name of FXIa-IN-8? |
| A: The English name of FXIa-IN-8 is FXIa-IN-8. |