Lapatinib-d5

Modify Date: 2024-04-08 14:26:12

Lapatinib-d5 Structure
Lapatinib-d5 structure
Common Name Lapatinib-d5
CAS Number 2748212-14-6 Molecular Weight 586.09
Density N/A Boiling Point N/A
Molecular Formula C29H21D5ClFN4O4S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Lapatinib-d5


Lapatinib-d5 is deuterium labeled Lapatinib. Lapatinib (GW572016) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively[1].

 Names

Name Lapatinib-d5

 Lapatinib-d5 Biological Activity

Description Lapatinib-d5 is deuterium labeled Lapatinib. Lapatinib (GW572016) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively[1].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Rusnak DW, et al. The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo. Mol Cancer Ther. 2001 Dec;1(2):85-94

 Chemical & Physical Properties

Molecular Formula C29H21D5ClFN4O4S
Molecular Weight 586.09