Mebeverine hydrochloride

Modify Date: 2024-01-02 22:05:14

Mebeverine hydrochloride Structure
Mebeverine hydrochloride structure
Common Name Mebeverine hydrochloride
CAS Number 2753-45-9 Molecular Weight 466.01000
Density N/A Boiling Point 543.8ºC at 760mmHg
Molecular Formula C25H36ClNO5 Melting Point 105-107ºC
MSDS Chinese USA Flash Point 282.7ºC
Symbol GHS07
GHS07
Signal Word Warning

 Names

Name Mebeverine Hydrochloride
Synonym More Synonyms

 Chemical & Physical Properties

Boiling Point 543.8ºC at 760mmHg
Melting Point 105-107ºC
Molecular Formula C25H36ClNO5
Molecular Weight 466.01000
Flash Point 282.7ºC
Exact Mass 465.22800
PSA 57.23000
LogP 5.40450
Vapour Pressure 6.92E-12mmHg at 25°C
Storage condition 2-8°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YX5425000
CHEMICAL NAME :
Veratric acid, 4-(ethyl(p-methoxy-alpha-methylphenethyl)amino)butyl ester, hydrochloride
CAS REGISTRY NUMBER :
2753-45-9
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C25-H35-N-O5.Cl-H
MOLECULAR WEIGHT :
466.07
WISWESSER LINE NOTATION :
1OR BO1 DVO4N2&Y1&1R DO1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1540 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GWXXBX German Offenlegungsschrift Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2821584
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
17700 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GWXXBX German Offenlegungsschrift Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2821584
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,338,1972

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn: Harmful;
Risk Phrases R22
Safety Phrases 36-26
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS YX5425000

 Articles26

More Articles
Validated chromatographic and spectrophotometric methods for analysis of some amoebicide drugs in their combined pharmaceutical preparation.

Pak. J. Pharm. Sci. 26(1) , 175-83, (2013)

This work is concerned with development and validation of chromatographic and spectrophotometric methods for analysis of mebeverine HCl (MEH), diloxanide furoate (DF) and metronidazole (MET) in Dimetr...

Preparation and in vitro evaluation of mebeverine HCl colon-targeted drug delivery system.

Pharm. Dev. Technol. 16(4) , 331-42, (2011)

Mebeverine HCl is a water soluble drug commonly used to treat irritable bowel syndrome by acting directly on the smooth muscles of the colon. This work was aimed at the formulation and in vitro evalua...

Quantitative HPLC analysis of mebeverine, mesalazine, sulphasalazine and dispersible aspirin stored in a Venalink monitored dosage system with co-prescribed medicines.

J. Pharm. Biomed. Anal. 54(4) , 646-52, (2011)

An HPLC method for the quantitative analysis of mebeverine HCl, 5-aminosalicylic acid (5-ASA), sulphasalazine and dispersible aspirin has been developed and then applied to these specific medicines wh...

 Synonyms

MFCD00867721
MebeverineHydrochloride
Mebeverine hydrochloride
4-[ethyl-[1-(4-methoxyphenyl)propan-2-yl]amino]butyl 3,4-dimethoxybenzoate,hydrochloride
EINECS 220-400-0
Mebeverine (hydrochloride)
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