Bcl-2-IN-11

Modify Date: 2024-01-29 19:35:05

Bcl-2-IN-11 structure	Common Name	Bcl-2-IN-11
	CAS Number	2760536-88-5	Molecular Weight	902.43
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₄₅H₄₉ClFN₇O₈S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Bcl-2-IN-11

Bcl-2-IN-11 (compound 6) is a potent and selective Bcl-2 activity inhibitor, with an IC50 of 0.9 nM. Bcl-2-IN-11 shows weak inhibition of Bcl-xl (IC50 > 1000 nM). Bcl-2-IN-11 can be used for the research of a variety of cancers caused by abnormal overexpression of Bcl-2 family proteins: especially malignant hematologic diseases of acute lymphoid leukemia, etc. Bcl-2-IN-11 can also avoid toxic side effects caused by Bcl-xl inhibition, such as thrombocytopenia[1].

Name	Bcl-2-IN-11

Description	Bcl-2-IN-11 (compound 6) is a potent and selective Bcl-2 activity inhibitor, with an IC50 of 0.9 nM. Bcl-2-IN-11 shows weak inhibition of Bcl-xl (IC50 > 1000 nM). Bcl-2-IN-11 can be used for the research of a variety of cancers caused by abnormal overexpression of Bcl-2 family proteins: especially malignant hematologic diseases of acute lymphoid leukemia, etc. Bcl-2-IN-11 can also avoid toxic side effects caused by Bcl-xl inhibition, such as thrombocytopenia[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Bcl-2 Family Research Areas >> Cancer
Target	Bcl-2:0.9 nM (IC50) Bcl-xL:>1000 nM (IC50)
References	[1]. Kong Xianglong, et al. Heterocyclic compound as bcl-2 inhibitor. WO2022028353A1.

Molecular Formula	C₄₅H₄₉ClFN₇O₈S
Molecular Weight	902.43

Bcl-2-IN-11

Use of Bcl-2-IN-11

Names

Bcl-2-IN-11 Biological Activity

Chemical & Physical Properties