5-epi-Arvestonate A
Modify Date: 2024-01-16 10:59:49
5-epi-Arvestonate A structure
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Common Name | 5-epi-Arvestonate A | ||
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| CAS Number | 2767066-84-0 | Molecular Weight | 298.37 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H26O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of 5-epi-Arvestonate A5-epi-Arvestonate A is a sesquiterpenoid isolated from the whole plants of Seriphidium transiliense. 5-epi-Arvestonate A promotes melanogenic production by activating the transcription of microphthalmia-associated transcription factor (MITF) and tyrosinase family genes. 5-epi-Arvestonate A inhibits the expression of IFN-γ-chemokine through the JAK/STAT signaling pathway in immortalized human keratinocyte (HaCaT) cells[1]. |
| Name | 5-epi-Arvestonate A |
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| Description | 5-epi-Arvestonate A is a sesquiterpenoid isolated from the whole plants of Seriphidium transiliense. 5-epi-Arvestonate A promotes melanogenic production by activating the transcription of microphthalmia-associated transcription factor (MITF) and tyrosinase family genes. 5-epi-Arvestonate A inhibits the expression of IFN-γ-chemokine through the JAK/STAT signaling pathway in immortalized human keratinocyte (HaCaT) cells[1]. |
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| Related Catalog | |
| In Vitro | 5-epi-Arvestonate A (50 μM; 48 h) activates the transcription of microphthalmia-associated transcription factor (MITF) and tyrosinase family genes in murine melanoma (B16) cells[1]. 5-epi-Arvestonate A (50 μM; 48 h) increases both the mRNA and protein level of TRP-1, TRP-2, TYR, and MITF in murine melanoma (B16) cells[1]. 5-epi-Arvestonate A (10 μM, 50 μM; 24 h) disrupts the IFN-γ-chemokine and CXCL10/9 production through the JAK/STAT signal pathway in IFN-γ-activated HaCaT cells[1]. Western Blot Analysis[1] Cell Line: Murine melanoma (B16) cells; IFN-γ-activated HaCaT cells Concentration: 1, 10, 50 μM Incubation Time: 24 hours and 48 hours Result: Increased the protein level of TRP-1, TRP-2, TYR, and MITF at 50 μM concentration in murine melanoma (B16) cells. Decreased the protein level of IFN-γ, CXCL9/10 in IFN-γ-activated HaCaT cells for 24 hr. Cell Viability Assay[1] Cell Line: Murine melanoma (B16) cells Concentration: 1, 10, 50 μM Incubation Time: 48 hours Result: Increased the viability of B16, increased the levels of both relative melanin content and relative tyrosinase activity. |
| Molecular Formula | C16H26O5 |
|---|---|
| Molecular Weight | 298.37 |