CDK2/4/6-IN-1

Modify Date: 2025-08-25 16:36:51

CDK2/4/6-IN-1 Structure
CDK2/4/6-IN-1 structure
Common Name CDK2/4/6-IN-1
CAS Number 2803837-13-8 Molecular Weight 438.50
Density N/A Boiling Point N/A
Molecular Formula C22H22N4O4S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of CDK2/4/6-IN-1


CDK2/4/6-IN-1(example 29) is a CDK2/4/6 inhibitor with IC50 values of 2.5, 23.7 and 44.3 nM for CDK2, CDK4 and CDK6, respectively. CDK2/4/6-IN-1 can be used in cancer research[1].

 Names

Name CDK2/4/6-IN-1

 CDK2/4/6-IN-1 Biological Activity

Description CDK2/4/6-IN-1(example 29) is a CDK2/4/6 inhibitor with IC50 values of 2.5, 23.7 and 44.3 nM for CDK2, CDK4 and CDK6, respectively. CDK2/4/6-IN-1 can be used in cancer research[1].
Related Catalog
Target

CDK2:2.5 nM (IC50)

CDK4:23.7 nM (IC50)

CDK6:44.3 nM (IC50)

In Vitro CDK2/4/6-IN-1(example 29) (0-600 nM, 24 h) inhibits the proliferation of OVCAR3 and MCF7 cells with the IC50 values of 14.6 and 117.8 nM, respectively[1]. CDK2/4/6-IN-1(example 29) (0-600 nM, 24 h) inhibits phosphorylation of Rb protein in OVCAR3 and MCF7 cells with the IC50 values of 18 and 581 nM, respectively[1].
In Vivo CDK2/4/6-IN-1(example 29) (25 mg/kg or 50 mg/kg, once a day, orally) has a significant inhibitory effect on tumor growth[1]. The pharmacokinetic parameters of example 29 in BALB/c mice (10 mg/kg, p.o.) Parameters Cmax(ng/mL) Tmax(hr) AUClast(hr*ng/mL) T1/2(hr) PO 4050 0.5 10050 4.8The pharmacokinetic parameters of example 29 in BALB/c mice (3 mg/kg, i.v.) Parameters C0(ng/mL) T1/2(hr) AUClast(hr*ng/mL) Vss(L/Kg) IV 4407 0.7 3245 0.9
References

[1]. ZHANG YAN, et al. Cdk2/4/6 inhibitor, preparation method therefor, and application thereof. WO2022152259 A1.

 Chemical & Physical Properties

Molecular Formula C22H22N4O4S
Molecular Weight 438.50
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