SPT-IN-1

Modify Date: 2024-01-16 13:51:00

SPT-IN-1 structure	Common Name	SPT-IN-1
	CAS Number	1933533-18-6	Molecular Weight	364.44
	Density	1.2±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₂₂H₂₄N₂O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of SPT-IN-1

SPT-IN-1 (compound 1) is an orally active and potent SPT (serine palmitoyl transferase) inhibitor, with an IC50 of 5.19 nM for hSPT1. SPT-IN-1 can be used for type 2 diabetes and dyslipidemia research[1].

Name	SPT Imidazopyridine 1
Synonym	More Synonyms

Description	SPT-IN-1 (compound 1) is an orally active and potent SPT (serine palmitoyl transferase) inhibitor, with an IC50 of 5.19 nM for hSPT1. SPT-IN-1 can be used for type 2 diabetes and dyslipidemia research[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
Target	IC50: 5.19 nM (hSPT1)[1]
In Vitro	SPT-IN-1 (compound 1) exhibits a dose-dependent inhibition of C14-serine incorporation into ceramide in MCF-7 cells, with EC50 of 0.98 μM[1].
In Vivo	SPT-IN-1 (compound 1) (Sprague Dawley rats, 0-60 mg/kg, Orally, twice daily for 7 days) dose-dependently reduces plasma ceramides, reduces triglycerides and raises HDL in cholesterol/cholic acid fed rats[1].
References	[1]. Genin MJ, et al. Imidazopyridine and Pyrazolopiperidine Derivatives as Novel Inhibitors of Serine Palmitoyl Transferase. J Med Chem. 2016;59(12):5904-5910.

Density	1.2±0.1 g/cm3
Molecular Formula	C₂₂H₂₄N₂O₃
Molecular Weight	364.44
Exact Mass	364.178680
LogP	3.78
Index of Refraction	1.603

MFCD31579859

[4-(6-Heptanoylimidazo[1,2-a]pyridin-8-yl)phenyl]acetic acid

Benzeneacetic acid, 4-[6-(1-oxoheptyl)imidazo[1,2-a]pyridin-8-yl]-

4-[6-(1-Oxoheptyl)imidazo[1,2-a]pyridin-8-yl]benzeneacetic acid

SPT-IN-1

Use of SPT-IN-1

Names

SPT-IN-1 Biological Activity

Chemical & Physical Properties

Synonyms