Uridine 5′-diphosphoglucose disodium salt

Modify Date: 2025-08-22 21:59:18

Uridine 5′-diphosphoglucose disodium salt structure	Common Name	Uridine 5′-diphosphoglucose disodium salt
	CAS Number	28053-08-9	Molecular Weight	456.231
	Density	1.9±0.1 g/cm3	Boiling Point	780.3±70.0 °C at 760 mmHg
	Molecular Formula	C₁₅H₂₂N₂Na₂O₁₇P₂	Melting Point	N/A
	MSDS	USA	Flash Point	425.7±35.7 °C

Use of Uridine 5′-diphosphoglucose disodium salt

Uridine 5′-diphosphoglucose disodium salt (UDP-D-Glucose disodium salt) is the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine-5′-diphosphoglucose is an agonist of the P2Y14 receptor, a neuroimmune system GPCR[1].

Name	Uridine 5'-Diphosphoglucose Disodium Salt
Synonym	More Synonyms

Description	Uridine 5′-diphosphoglucose disodium salt (UDP-D-Glucose disodium salt) is the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine-5′-diphosphoglucose is an agonist of the P2Y14 receptor, a neuroimmune system GPCR[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
References	[1]. DietrichKeppler, et al. Uridine-5′-diphosphoglucose. Methods of Enzymatic Analysis (Second English Edition). 1974;4:2225-2228. [2]. Das A, et al. Human P2Y(14) receptor agonists: truncation of the hexose moiety of uridine-5'-diphosphoglucose and its replacement with alkyl and aryl groups. J Med Chem. 2010 Jan 14;53(1):471-80.

Description

Related Catalog

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

References

[1]. DietrichKeppler, et al. Uridine-5′-diphosphoglucose. Methods of Enzymatic Analysis (Second English Edition). 1974;4:2225-2228.

[2]. Das A, et al. Human P2Y(14) receptor agonists: truncation of the hexose moiety of uridine-5'-diphosphoglucose and its replacement with alkyl and aryl groups. J Med Chem. 2010 Jan 14;53(1):471-80.

Density	1.9±0.1 g/cm3
Boiling Point	780.3±70.0 °C at 760 mmHg
Molecular Formula	C₁₅H₂₂N₂Na₂O₁₇P₂
Molecular Weight	456.231
Flash Point	425.7±35.7 °C
Exact Mass	456.043396
PSA	330.11000
LogP	-4.05
Vapour Pressure	0.0±6.1 mmHg at 25°C
Index of Refraction	1.612
InChIKey	PKJQEQVCYGYYMM-QBNUFUENSA-L
SMILES	O=c1ccn(C2OC(COP(=O)([O-])OP(=O)([O-])OC3OC(CO)C(O)C(O)C3O)C(O)C2O)c(=O)[nH]1.[Na+].[Na+]
Storage condition	−20°C
Water Solubility	H2O: soluble50mg/mL, clear

MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
HS Code	29400090

Hysteresis in human UDP-glucose dehydrogenase is due to a restrained hexameric structure that favors feedback inhibition.

Biochemistry 53(51) , 8043-51, (2014)

Human UDP-α-d-glucose-6-dehydrogenase (hUGDH) displays hysteresis because of a slow isomerization from an inactive state (E*) to an active state (E). Here we show that the structure of E* constrains h...

Transporter-mediated uptake of UDP-glucuronic acid by human liver microsomes: assay conditions, kinetics, and inhibition.

Drug Metab. Dispos. 43(1) , 147-53, (2014)

This study characterized the kinetics, variability, and factors that affect UDP-glucuronic acid (UDP-GlcUA) uptake by human liver microsomes (HLM). Biphasic kinetics were observed for UDP-GlcUA uptake...

UDP-glucose pyrophosphorylase influences polysaccharide synthesis, cell wall components, and hyphal branching in Ganoderma lucidum via regulation of the balance between glucose-1-phosphate and UDP-glucose.

Fungal Genet. Biol. 82 , 251-63, (2015)

UDP-glucose pyrophosphorylase (UGP) is a key enzyme involved in carbohydrate metabolism, but there are few studies on the functions of this enzyme in fungi. The ugp gene of Ganoderma lucidum was clone...

Name: Thermal Shift Assay. Domain: start/stop: N44-E168
Source: ChEMBL
Target: Bromodomain-containing protein 4
External Id: CHEMBL5060944

Name: Thermal Shift Assay. Domain start/stop: M626-G740
Source: ChEMBL
Target: Peregrin
External Id: CHEMBL4650107

Name: Thermal Shift Assay. Domain: start/stop: M1-L298
Source: ChEMBL
Target: Cyclin-dependent kinase 2
External Id: CHEMBL5062802

Name: Thermal Shift Assay. Domain: start/stop: E122-S403
Source: ChEMBL
Target: Aurora kinase A
External Id: CHEMBL5067447

Name: GPCR beta-arrestin recruitment assay with target: GPR35 Assay Type: PRESTO-Tango Conc...
Source: ChEMBL
Target: G-protein coupled receptor 35
External Id: CHEMBL5209835

Name: Thermal Shift Assay. Domain: start/stop: M26-R383
Source: ChEMBL
Target: Glycogen synthase kinase-3 beta
External Id: CHEMBL5066424

Name: Thermal Shift Assay. Domain: start/stop: E122-S403
Source: ChEMBL
Target: Aurora kinase A
External Id: CHEMBL5068282

Name: GPCR beta-arrestin recruitment assay with target: S1PR1 Assay Type: PRESTO-Tango Conc...
Source: ChEMBL
Target: Sphingosine 1-phosphate receptor 1
External Id: CHEMBL5209836

Name: Thermal Shift Assay. Domain: start/stop: M1-K294
Source: ChEMBL
Target: Casein kinase I isoform delta
External Id: CHEMBL5063731

Name: Thermal Shift Assay. Domain: start/stop: M626-G740
Source: ChEMBL
Target: Peregrin
External Id: CHEMBL5062708

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disodium,[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] [(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] phosphate

UDP-Glc UDP-glucose UDPG

UDP-glc

(3,4-Dihydroxytetrahydro-2-furanyl)methyl 3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl dihydrogen diphosphate