Stepharine
Modify Date: 2024-01-01 21:16:44
Stepharine structure
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Common Name | Stepharine | ||
|---|---|---|---|---|
| CAS Number | 2810-21-1 | Molecular Weight | 297.34800 | |
| Density | 1.27g/cm3 | Boiling Point | 487.1ºC at 760 mmHg | |
| Molecular Formula | C18H19NO3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 248.4ºC | |
Use of StepharineStepharine, an natural alkaloid, directly interactes with TLR4 and binds to the TLR4/MD2 complex (TLR4 inhibitor). Stepharine possesses anti-aging, anti-viral and anti-hypertensive effects[1]. |
| Name | Stepharine |
|---|---|
| Synonym | More Synonyms |
| Description | Stepharine, an natural alkaloid, directly interactes with TLR4 and binds to the TLR4/MD2 complex (TLR4 inhibitor). Stepharine possesses anti-aging, anti-viral and anti-hypertensive effects[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Stepharine (10, 30 μM) substantially inhibits nitric oxide (NO) release as well as the mRNA and protein expression of pro-inflammatory mediators [inducible nitric oxide synthase, interleukin (IL)-6, tumor necrosis factor (TNF)-α, IL-1β] in LPS-activated BV-2 cells[1]. Stepharine (10, 30 μM) inhibits LPS-induced increase of TLR4 expression, IκBα phosphorylation, and NF-κB p65 nuclear translocation[1]. Stepharine exhibits neuroprotective effects on SH-SY5Y cells cultured with LPS-treated conditioned medium. Stepharine has also shown to inhibit cholinesterase in vitro[1]. |
| In Vivo | Stepharine (500 μg/kg) inhibited NeuN+ cells loss and Iba-1+ cells increase in the MCAO ischemic cortex[1]. Animal Model: Middle cerebral artery occlusion (MCAO) rat model[1]. Dosage: 500 μg/kg (20 μL). Administration: Intranasally injected into rats 1h after MCAO. Result: Attenuated the neuronal loss induced by MCAO (MCAO+ stepharine) group. |
| References |
| Density | 1.27g/cm3 |
|---|---|
| Boiling Point | 487.1ºC at 760 mmHg |
| Molecular Formula | C18H19NO3 |
| Molecular Weight | 297.34800 |
| Flash Point | 248.4ºC |
| Exact Mass | 297.13600 |
| PSA | 47.56000 |
| LogP | 2.55600 |
| Vapour Pressure | 1.22E-09mmHg at 25°C |
| Index of Refraction | 1.632 |
| hms1607i01 |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Stepharine
- Price: Negotiable
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Tom
- Email: sales@echemcloud.com
- BioBioPha
- China
- Product Name: Stepharine
- Price: ￥3400.0/5mg
- Purity: 98.0%
- Delivery: 1 Day
- Contact: Xueping-Zheng
- Email: 1477035482@qq.com
- DC Chemicals Limited
- China
- Product Name: Stepharine
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: Spiro[2,5-cyclohexadiene-1,7'(1'H)-cyclopent[ij]isoquinolin]-4-one,2',3',8',8'a-tetrahydro-5',6'-dimethoxy-, (8'aR)-
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Delivery: Inquiry
- Contact: Ms Wang
- Email: enquiry@dycnchem.com
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