WD2000-012547

Modify Date: 2024-01-10 11:54:16

WD2000-012547 structure	Common Name	WD2000-012547
	CAS Number	283172-68-9	Molecular Weight	262.30600
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₇H₁₄N₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of WD2000-012547

WD2000-012547 is a selective poly(ADP-ribose)-polymerase (PARP-1) inhibitor with a pKi of 8.221.

Name	2-phenyl-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indol-6-one
Synonym	More Synonyms

Description	WD2000-012547 is a selective poly(ADP-ribose)-polymerase (PARP-1) inhibitor with a pKi of 8.221.
Related Catalog	Research Areas >> Cancer
Target	PARP-1:8.221 (pKi)
In Vitro	Poly(ADP-ribose) polymerase-1 (PARP-1) functions as a DNA damage sensor and signaling molecule. It plays a vital role in the repair of DNA strand breaks induced by radiation and chemotherapeutic drugs; inhibitors of this enzyme have the potential to improve cancer chemotherapy or radiotherapy. WD2000-012547 (Compound 66) is a representative PARP-1 inhibitor with a pKi of 8.221[1].
References	[1]. Fatima S, et al. Multiple receptor conformation docking, dock pose clustering and 3D QSAR studies on human poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. J Recept Signal Transduct Res. 2014 Oct;34(5):417-30.

Molecular Formula	C₁₇H₁₄N₂O
Molecular Weight	262.30600
Exact Mass	262.11100
PSA	44.89000
LogP	3.44960
Storage condition	2-8℃

WD2000-012547

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: WD2000-012547?
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Purity: 98.0%
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