6-Ethoxydihydrosanguinarine

Modify Date: 2026-07-09 10:59:56

6-Ethoxydihydrosanguinarine structure	Common Name	6-Ethoxydihydrosanguinarine
	CAS Number	28342-31-6	Molecular Weight	377.390
	Density	1.5±0.1 g/cm3	Boiling Point	563.7±50.0 °C at 760 mmHg
	Molecular Formula	C₂₂H₁₉NO₅	Melting Point	210-212℃(ethanol)
	MSDS	N/A	Flash Point	169.0±27.3 °C

Use of 6-Ethoxydihydrosanguinarine

Ethoxysanguinarine is a benzophenanthridine alkaloid natural product that is mainly found in Macleaya cordata. Ethoxysanguinarine inhibits viability and induces apoptosis of colorectal cancer cells by inhibiting protein phosphatase 2A (CIP2A)[1].

Name	6-Ethoxy-5,6-dihydrosanguinarine
Synonym	More Synonyms

Description	Ethoxysanguinarine is a benzophenanthridine alkaloid natural product that is mainly found in Macleaya cordata. Ethoxysanguinarine inhibits viability and induces apoptosis of colorectal cancer cells by inhibiting protein phosphatase 2A (CIP2A)[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
References	[1]. Jin L, et al. Ethoxysanguinarine inhibits viability and induces apoptosis of colorectal cancer cells by inhibiting CIP2A. Int J Oncol. 2018 Mar 16.

Density	1.5±0.1 g/cm3
Boiling Point	563.7±50.0 °C at 760 mmHg
Melting Point	210-212℃(ethanol)
Molecular Formula	C₂₂H₁₉NO₅
Molecular Weight	377.390
Flash Point	169.0±27.3 °C
Exact Mass	377.126312
PSA	50.03000
LogP	4.45
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.724
InChIKey	FCEXWTOTHXCQCQ-UHFFFAOYSA-N
SMILES	CCOC1c2c(ccc3c2OCO3)-c2ccc3cc4c(cc3c2N1C)OCO4

HS Code	2933990090

Ethanol

CAS#:64-17-5

sanguinarium ch...

CAS#:5578-73-4

~98%

6-Ethoxydihydro...

CAS#:28342-31-6

Learn More

Literature: Miao, Fang; Yang, Xin-Juan; Ma, Yan-Ni; Zheng, Feng; Song, Xiao-Ping; Zhou, Le Chemical and Pharmaceutical Bulletin, 2012 , vol. 60, # 12 p. 1508 - 1513

Sodium ethoxide

CAS#:141-52-6

SANGUINARINE

CAS#:2447-54-3

~42%

6-Ethoxydihydro...

CAS#:28342-31-6

Learn More

Literature: Miao, Fang; Yang, Xin-Juan; Zhou, Le; Hu, Hai-Jun; Zheng, Feng; Ding, Xu-Dong; Sun, Dong-Mei; Zhou, Chun-Dong; Sun, Wei Natural Product Research, 2011 , vol. 25, # 9 p. 863 - 875

Ethanol

CAS#:64-17-5

N/A

CAS#:4070-41-1

6-Ethoxydihydro...

CAS#:28342-31-6

Learn More

Literature: Stermitz; Larson; Kim Journal of Medicinal Chemistry, 1973 , vol. 16, # 8 p. 939 - 940

Precursor 4
CAS#:64-17-5 Ethanol CAS#:5578-73-4 sanguinarium ch... CAS#:141-52-6 Sodium ethoxide CAS#:2447-54-3 SANGUINARINE
DownStream 1
CAS#:28342-26-9 Dihydrochelirubine

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Name: Induction of apoptosis in human NCI-H1975 cells at 0.5 to 2.5 uM after 24 hrs by anne...
Source: ChEMBL
Target: NCI-H1975
External Id: CHEMBL3117692

Name: Cytotoxicity against human A549 cells assessed as growth inhibition at 5 uM after 24 ...
Source: ChEMBL
Target: A549
External Id: CHEMBL3117888

Name: Inhibition of CIP2A in human A549 cells assessed as induction of PP2A activity at 5 u...
Source: ChEMBL
Target: Protein CIP2A
External Id: CHEMBL3117889

Name: Downregulation of total AKT protein expression in human A549 cells at 1 to 10 uM afte...
Source: ChEMBL
Target: A549
External Id: CHEMBL3117890

Name: Inhibition of CIP2A in human A549 cells assessed as downregulation of p-AKT protein e...
Source: ChEMBL
Target: Protein CIP2A
External Id: CHEMBL3117891

Name: Inhibition of CIP2A in human A549 cells assessed as downregulation of c-Myc protein e...
Source: ChEMBL
Target: Protein CIP2A
External Id: CHEMBL3117892

Name: Downregulation of total AKT protein expression in human NCI-H1975 cells at 1 to 2.5 u...
Source: ChEMBL
Target: NCI-H1975
External Id: CHEMBL3117893

Name: Inhibition of CIP2A in human NCI-H1975 cells assessed as downregulation of p-AKT prot...
Source: ChEMBL
Target: Protein CIP2A
External Id: CHEMBL3117894

Name: Inhibition of CIP2A in human NCI-H1975 cells assessed as downregulation of c-Myc prot...
Source: ChEMBL
Target: Protein CIP2A
External Id: CHEMBL3117895

Name: Inhibition of CIP2A in human A549 cells assessed as potentiation of cisplatin-induced...
Source: ChEMBL
Target: Protein CIP2A
External Id: CHEMBL3117677

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6-ethoxydihydrosanguinarine

Sanguinarin

ethoxysanguinarine

O-ethyl-sanguinarine

14-Ethoxy-13-methyl-13,14-dihydro[1,3]benzodioxolo[5,6-c][1,3]dioxolo[4,5-i]phenanthridine

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Product Name: 14-ETHOXY-13-METHYL-13,14-DIHYDRO-[1,3]DIOXOLO[4',5':4,5]BENZO[1,2-C][1,3]DIOXOLO[4,5-I]PHENANTHRIDINE
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China
Product Name: 6-Ethoxydihydrosanguinarine
Price: ￥Inquiry/5mg ￥Inquiry/20mg ￥Inquiry/100mg ￥Inquiry/1g
Purity: 98.0%
Delivery: Inquiry
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6-Ethoxydihydrosanguinarine

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