7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2-oxo-2H-1,4-benzodiazepin-3-yl acetate

Modify Date: 2024-01-16 18:30:10

7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2-oxo-2H-1,4-benzodiazepin-3-yl acetate Structure
7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2-oxo-2H-1,4-benzodiazepin-3-yl acetate structure
Common Name 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2-oxo-2H-1,4-benzodiazepin-3-yl acetate
CAS Number 2848-96-6 Molecular Weight 363.19500
Density 1.45 g/cm3 Boiling Point 524.4ºC at 760 mmHg
Molecular Formula C17H12Cl2N2O3 Melting Point N/A
MSDS N/A Flash Point 270.9ºC
Symbol GHS07 GHS09
GHS07, GHS09
Signal Word Warning

 Names

Name [7-chloro-5-(2-chlorophenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl] acetate
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.45 g/cm3
Boiling Point 524.4ºC at 760 mmHg
Molecular Formula C17H12Cl2N2O3
Molecular Weight 363.19500
Flash Point 270.9ºC
Exact Mass 362.02200
PSA 67.76000
LogP 3.24570
Vapour Pressure 4.33E-11mmHg at 25°C
Index of Refraction 1.656

 Safety Information

Symbol GHS07 GHS09
GHS07, GHS09
Signal Word Warning
Hazard Statements H302-H410
Precautionary Statements P273-P501
RIDADR UN 3077 9 / PGIII

 Synthetic Route

~90%

7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2-oxo-2H-1,4-benzodiazepin-3-yl acetate Structure

7-chloro-5-(2-c...

CAS#:2848-96-6

Literature: Cepanec, Ivica; Litvic, Mladen; Pogorelic, Ivan Organic Process Research and Development, 2006 , vol. 10, # 6 p. 1192 - 1198

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7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2-oxo-2H-1,4-benzodiazepin-3-yl acetate Structure

7-chloro-5-(2-c...

CAS#:2848-96-6

Literature: Cepanec, Ivica; Litvic, Mladen; Pogorelic, Ivan Organic Process Research and Development, 2006 , vol. 10, # 6 p. 1192 - 1198

~%

7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2-oxo-2H-1,4-benzodiazepin-3-yl acetate Structure

7-chloro-5-(2-c...

CAS#:2848-96-6

Literature: Cepanec, Ivica; Litvic, Mladen; Pogorelic, Ivan Organic Process Research and Development, 2006 , vol. 10, # 6 p. 1192 - 1198

 Articles7

More Articles
Stereoselective binding of 3-acetoxy-, and 3-hydroxy-1,4-benzodiazepine-2-ones to human serum albumin. Selective allosteric interaction with warfarin enantiomers.

Biochem. Pharmacol. 35(2) , 263-9, (1986)

Stereoselective binding of oxazepam, lorazepam, temazepam and methyl lorazepam as well as of their acetates to human serum albumin was investigated by different techniques. The 2'-chlorine and the N(1...

Stereoselective kinetics of warfarin binding to human serum albumin: effect of an allosteric interaction.

Chirality 14(5) , 442-8, (2002)

Kinetic and equilibrium binding studies were performed on the interaction of warfarin enantiomers with human serum albumin (HSA) in the absence and presence of lorazepam acetate (LoAc) enantiomers. Bi...

Stereoselective allosteric binding interaction on human serum albumin between ibuprofen and lorazepam acetate.

Chirality 11(2) , 115-20, (1999)

The effect of ibuprofen enantiomers on the stereoselective binding of 3-acyloxy-1,4-benzodiazepines to human serum albumin (HSA) was studied using both native and Sepharose-immobilized protein. (S)-Lo...

 Synonyms

lorazepam acetate