Cyclo(-Pro-Val)

Modify Date: 2025-08-25 18:42:37

Cyclo(-Pro-Val) Structure
Cyclo(-Pro-Val) structure
Common Name Cyclo(-Pro-Val)
CAS Number 2854-40-2 Molecular Weight 196.25
Density N/A Boiling Point N/A
Molecular Formula C10H16N2O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Cyclo(-Pro-Val)


Cyclo(L-Pro-L-Val) is a 2,5-diketopiperazine, with toxic activity against phytopathogenic microorganisms (such as R. fascians LMG 3605). Cyclo(L-Pro-L-Val) shows toxicity similar to Chloramphenicol (HY-B0239) with comparable concentration. Cyclo(L-Pro-L-Val) can also inhibit gram-positive phytopathogenic bacterium. Cyclo(L-Pro-L-Val) has potential development as biopesticide[1].

 Names

Name (3S,8aS)-3-propan-2-yl-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
Synonym More Synonyms

 Cyclo(-Pro-Val) Biological Activity

Description Cyclo(L-Pro-L-Val) is a 2,5-diketopiperazine, with toxic activity against phytopathogenic microorganisms (such as R. fascians LMG 3605). Cyclo(L-Pro-L-Val) shows toxicity similar to Chloramphenicol (HY-B0239) with comparable concentration. Cyclo(L-Pro-L-Val) can also inhibit gram-positive phytopathogenic bacterium. Cyclo(L-Pro-L-Val) has potential development as biopesticide[1].
Related Catalog
References

[1]. Cimmino A, et al. Isolation of 2,5-diketopiperazines from Lysobacter capsici AZ78 with activity against Rhodococcus fascians. Nat Prod Res. 2021 Dec;35(23):4969-4977.  

 Chemical & Physical Properties

Molecular Formula C10H16N2O2
Molecular Weight 196.25
Exact Mass 196.12100
PSA 49.41000
LogP 0.39850
InChIKey XLUAWXQORJEMBD-YUMQZZPRSA-N
SMILES CC(C)C1NC(=O)C2CCCN2C1=O

 Safety Information

HS Code 2933990090

 Synthetic Route

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Cyclo(-Pro-Val)Bioassay

View more

Name: Anti-inflammatory activity in human neutrophils assessed as inhibition of FMLP/CB-ind...
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL1826242
Name: Displacement of [3H]substance P from NK1 receptor in human astrocytoma cells at 200 u...
Source: ChEMBL
Target: Substance-P receptor
External Id: CHEMBL941113
Name: Antibacterial activity against Bacillus cereus after 2 days by disk assay
Source: ChEMBL
Target: Bacillus cereus
External Id: CHEMBL1028402
Name: Antibacterial activity against Micrococcus luteus after 2 days by disk assay
Source: ChEMBL
Target: Micrococcus luteus
External Id: CHEMBL1028403
Name: Antioxidant activity assessed DPPH scavenging activity at 500 uM
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL1826537
Name: Inhibition of recombinant human P-gp ATPase activity in presence of MgATP preincubate...
Source: ChEMBL
Target: ATP-dependent translocase ABCB1
External Id: CHEMBL5107730
Name: Cytotoxicity against human HCT-116 cells assessed as reduction on cell viability at 1...
Source: ChEMBL
Target: HCT-116
External Id: CHEMBL5107727
Name: Cytotoxicity against human wild type HCT-116 cells assessed as reduction on cell viab...
Source: ChEMBL
Target: HCT-116
External Id: CHEMBL5107728
Name: Cytotoxicity against paclitaxel-resistant human HCT116tax cells assessed as reduction...
Source: ChEMBL
Target: N/A
External Id: CHEMBL5107729
Name: Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs by agar diffu...
Source: ChEMBL
Target: Escherichia coli
External Id: CHEMBL3602538
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 Synonyms

Cyclo(-Pro-Val)
cyclo-(L-Val-L-Pro)
cyclo(-L-pro-L-val-)
(3S,8aS)-3-Isopropylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione
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