RDR03871

Modify Date: 2024-01-01 13:26:06

RDR03871 Structure
RDR03871 structure
Common Name RDR03871
CAS Number 286008-51-3 Molecular Weight 408.81
Density N/A Boiling Point N/A
Molecular Formula C18H16ClF3N6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of RDR03871


RDR03871 (compound 2) is a potent dual MDM2/MDM4 inhibitor with IC50 values of 35.4 nM and 10.4 nM for MDM2-p53 and MDM4-p53, respectively[1].

 Names

Name 1,2-Ethanediamine, N1-[5-chloro-6-methyl-2-(2-pyridinyl)-4-pyrimidinyl]-N2-[6-(trifluoromethyl)-2-pyridinyl]-

 RDR03871 Biological Activity

Description RDR03871 (compound 2) is a potent dual MDM2/MDM4 inhibitor with IC50 values of 35.4 nM and 10.4 nM for MDM2-p53 and MDM4-p53, respectively[1].
Related Catalog
References

[1]. Mariateresa Giustiniano, et al. Computer-Aided Identification and Lead Optimization of Dual Murine Double Minute 2 and 4 Binders: Structure-Activity Relationship Studies and Pharmacological Activity. J Med Chem. 2017 Oct 12;60(19):8115-8130.  

 Chemical & Physical Properties

Molecular Formula C18H16ClF3N6
Molecular Weight 408.81
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