Fesoterodine Fumarate

Modify Date: 2024-01-02 15:19:05

Fesoterodine Fumarate Structure
Fesoterodine Fumarate structure
Common Name Fesoterodine Fumarate
CAS Number 286930-03-8 Molecular Weight 527.649
Density N/A Boiling Point 518.9ºC at 760 mmHg
Molecular Formula C30H41NO7 Melting Point 72-78ºC
MSDS N/A Flash Point 267.6ºC

 Use of Fesoterodine Fumarate


Fesoterodine Fumarate is an antimuscarinic agent and is rapidly de-esterified to its active metabolite 5-hydroxymethyl tolterodine that is a muscarinic receptor antagonist.IC50 value:Target: mAChRFesoterodine has the advantage of allowing more flexible dosage than other muscarinic antagonists. Its tolerability and side effects are similar to other muscarinic antagonists and as a new drug seems unlikely to make great changes in practices of treatment for overactive bladder.

 Names

Name (E)-but-2-enedioic acid,[2-[(1R)-3-[di(propan-2-yl)amino]-1-phenylpropyl]-4-(hydroxymethyl)phenyl] 2-methylpropanoate
Synonym More Synonyms

 Fesoterodine Fumarate Biological Activity

Description Fesoterodine Fumarate is an antimuscarinic agent and is rapidly de-esterified to its active metabolite 5-hydroxymethyl tolterodine that is a muscarinic receptor antagonist.IC50 value:Target: mAChRFesoterodine has the advantage of allowing more flexible dosage than other muscarinic antagonists. Its tolerability and side effects are similar to other muscarinic antagonists and as a new drug seems unlikely to make great changes in practices of treatment for overactive bladder.
Related Catalog
References

[1]. Staskin David; Khullar Vik; Michel Martin C et al. Effects of voluntary dose escalation in a placebo-controlled, flexible-dose trial of fesoterodine in subjects with overactive bladder. Neurourology and urodynamics (2011), 30(8), 1480-5.

[2]. Vella Maria; Cardozo Linda Review of fesoterodine. Expert opinion on drug safety (2011), 10(5), 805-8.

[3]. Malhotra Bimal; Alvey Christine; Gong Jason et al. Effects of fesoterodine on the pharmacokinetics and pharmacodynamics of warfarin in healthy volunteers. British journal of clinical pharmacology (2011), 72(2), 257-62.

[4]. Michel MC. Fesoterodine: a novel muscarinic receptor antagonist for the treatment of overactive bladder syndrome. Expert Opin Pharmacother. 2008 Jul;9(10):1787-96.

[5]. Fesoterodine

 Chemical & Physical Properties

Boiling Point 518.9ºC at 760 mmHg
Melting Point 72-78ºC
Molecular Formula C30H41NO7
Molecular Weight 527.649
Flash Point 267.6ºC
Exact Mass 527.288330
PSA 124.37000
LogP 5.09290
Storage condition Hygroscopic, Store under Inert atmosphere -20°C Freezer

 Synonyms

(R)-Fesoterodine fumarate
Fesoterodine Fumarate
UNII-EOS72165S7
SPM 8272
SPM 907
Propanoic acid, 2-methyl-, 2-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-(hydroxymethyl)phenyl ester, (2E)-2-butenedioate (1:1)
Toviaz,Fesoterodine fumarate
2-[(1R)-3-(Diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)phenyl 2-methylpropanoate (2E)-2-butenedioate (1:1)
Propanoic acid,2-methyl-,2-((1R)-3-(bis(1-methylethyl)amino)-1-phenylpropyl)-4-(hydroxymethyl)phenyl ester,(2E)-2-butenedioate (1:1) (salt)
Fesoterodinefumarate
Toviaz
(R)-2-(3-(Diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyl)phenyl isobutyrate fumarate
Fesoterodine (fumarate)
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