富马酸非索罗定

• 常用名: 富马酸非索罗定
• 英文名: Fesoterodine Fumarate
• CAS号: 286930-03-8
• 分子量: 527.649
• 密度: N/A
• 沸点: 518.9ºC at 760 mmHg
• 分子式: C₃₀H₄₁NO₇
• 熔点: 72-78ºC
• 闪点: 267.6ºC

富马酸非索罗定名称

• 中文名: 富马酸非索罗定
• 英文名: (E)-but-2-enedioic acid,[2-[(1R)-3-[di(propan-2-yl)amino]-1-phenylpropyl]-4-(hydroxymethyl)phenyl] 2-methylpropanoate
• 中文别名: 非索罗定

富马酸非索罗定生物活性

• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR
  信号通路 >> 神经信号通路 >> mAChR
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Staskin David; Khullar Vik; Michel Martin C et al. Effects of voluntary dose escalation in a placebo-controlled, flexible-dose trial of fesoterodine in subjects with overactive bladder. Neurourology and urodynamics (2011), 30(8), 1480-5.

  [2]. Vella Maria; Cardozo Linda Review of fesoterodine. Expert opinion on drug safety (2011), 10(5), 805-8.

  [3]. Malhotra Bimal; Alvey Christine; Gong Jason et al. Effects of fesoterodine on the pharmacokinetics and pharmacodynamics of warfarin in healthy volunteers. British journal of clinical pharmacology (2011), 72(2), 257-62.

  [4]. Michel MC. Fesoterodine: a novel muscarinic receptor antagonist for the treatment of overactive bladder syndrome. Expert Opin Pharmacother. 2008 Jul;9(10):1787-96.

  [5]. Fesoterodine

富马酸非索罗定物理化学性质

• 沸点: 518.9ºC at 760 mmHg
• 熔点: 72-78ºC
• 分子式: C₃₀H₄₁NO₇
• 分子量: 527.649
• 闪点: 267.6ºC
• 精确质量: 527.288330
• PSA: 124.37000
• LogP: 5.09290
• InChIKey: MWHXMIASLKXGBU-RNCYCKTQSA-N
• SMILES: CC(C)C(=O)Oc1ccc(CO)cc1C(CCN(C(C)C)C(C)C)c1ccccc1.O=C(O)C=CC(=O)O
• 外观性状: 白色固体
• 储存条件: Hygroscopic, Store under Inert atmosphere -20°C Freezer

富马酸非索罗定靶点实验

查看更多实验

实验名称：Fluorescence-based biochemical high throughput primary assay to identify inhibitors o... 来源：The Scripps Research Institute Molecular Screening Center 靶标：Trypanosoma brucei RNA editing ligase 1 External Id：TBREL1_INH_FRET_1536_1X%INH PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based biochemical high throughput primary assay to identify inhibitors o... 来源：The Scripps Research Institute Molecular Screening Center 靶标：Phospholipase C, beta 3 (phosphatidylinositol-specific) [Homo sapiens] External Id：PLCB3_INH_QFRET_1536_1X%INH PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：ADAM10 [Homo sapiens] External Id：ADAM10_INH_QFRET_1536_1X%INH PRUN

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：abhydrolase domain-containing protein 4 isoform 1 [Mus musculus] External Id：ABHD4_INH_FP_1536_1X%INH PRUN

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify inh... 来源：The Scripps Research Institute Molecular Screening Center 靶标：COUP transcription factor 2 isoform a [Homo sapiens] External Id：COUPTFII_INH_LUMI_1536_1X%INH PRUN

实验名称：Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed ... 来源：ChEMBL 靶标：ATP-binding cassette sub-family C member 3 External Id：CHEMBL4028923

实验名称：Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as upta... 来源：ChEMBL 靶标：ATP-binding cassette sub-family C member 4 External Id：CHEMBL4028924

实验名称：Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as upta... 来源：ChEMBL 靶标：Bile salt export pump External Id：CHEMBL4028921

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富马酸非索罗定英文别名

• (R)-Fesoterodine fumarate
• Fesoterodine Fumarate
• UNII-EOS72165S7
• SPM 8272
• SPM 907
• Propanoic acid, 2-methyl-, 2-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-(hydroxymethyl)phenyl ester, (2E)-2-butenedioate (1:1)
• Toviaz,Fesoterodine fumarate
• 2-[(1R)-3-(Diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)phenyl 2-methylpropanoate (2E)-2-butenedioate (1:1)
• Propanoic acid,2-methyl-,2-((1R)-3-(bis(1-methylethyl)amino)-1-phenylpropyl)-4-(hydroxymethyl)phenyl ester,(2E)-2-butenedioate (1:1) (salt)
• Fesoterodinefumarate
• Toviaz
• (R)-2-(3-(Diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyl)phenyl isobutyrate fumarate
• Fesoterodine (fumarate)