Aurora Kinases-IN-4

Modify Date: 2025-08-21 10:18:22

Aurora Kinases-IN-4 structure	Common Name	Aurora Kinases-IN-4
	CAS Number	2877011-84-0	Molecular Weight	468.55
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₆H₂₈N₈O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Aurora Kinases-IN-4

Aurora Kinases-IN-4 (Compound 11c) is a covalent and ATP competitive aurora kinase A inhibitor (IC50: 1.7 nM). Aurora Kinases-IN-4 inhibits cell proliferation in SJSA-1, MDA-MB-231, A54, HeLa cells with IC50s of 4.27, 1.54, 3.08, 6.99 μM. Aurora Kinases-IN-4 can be used for research of triple negative breast cancer (TNBC)[1].

Name	Aurora Kinases-IN-4

Description	Aurora Kinases-IN-4 (Compound 11c) is a covalent and ATP competitive aurora kinase A inhibitor (IC50: 1.7 nM). Aurora Kinases-IN-4 inhibits cell proliferation in SJSA-1, MDA-MB-231, A54, HeLa cells with IC50s of 4.27, 1.54, 3.08, 6.99 μM. Aurora Kinases-IN-4 can be used for research of triple negative breast cancer (TNBC)[1].
Related Catalog	Signaling Pathways >> Epigenetics >> Aurora Kinase Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Aurora Kinase
References	[1]. Zhang B, et al. Discovery of a first-in-class Aurora A covalent inhibitor for the treatment of triple negative breast cancer. Eur J Med Chem. 2023 Aug 5;256:115457.

Molecular Formula	C₂₆H₂₈N₈O
Molecular Weight	468.55

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Aurora Kinases-IN-4

Use of Aurora Kinases-IN-4

Names

Aurora Kinases-IN-4 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.