CPD-1224

Modify Date: 2024-03-14 10:51:02

CPD-1224 Structure
CPD-1224 structure
Common Name CPD-1224
CAS Number 2891620-68-9 Molecular Weight 855.40
Density N/A Boiling Point N/A
Molecular Formula C43H47ClN8O7S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of CPD-1224


CPD-1224 is an orally active derivative of ALK inhibitors to cereblon ligands. CPD-1224 targets to EML4-ALK oncogenic fusions, and degrades ALK and mutant L1196M/G1202R[1].

 Names

Name CPD-1224

 CPD-1224 Biological Activity

Description CPD-1224 is an orally active derivative of ALK inhibitors to cereblon ligands. CPD-1224 targets to EML4-ALK oncogenic fusions, and degrades ALK and mutant L1196M/G1202R[1].
Related Catalog
References

[1]. Gao Y, et al. Catalytic Degraders Effectively Address Kinase Site Mutations in EML4-ALK Oncogenic Fusions. J Med Chem. 2023 Apr 10.  

 Chemical & Physical Properties

Molecular Formula C43H47ClN8O7S
Molecular Weight 855.40
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