P-gp inhibitor 14

Modify Date: 2024-01-04 18:40:54

P-gp inhibitor 14 structure	Common Name	P-gp inhibitor 14
	CAS Number	2892571-47-8	Molecular Weight	638.71
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₇H₃₈N₂O₈	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of P-gp inhibitor 14

P-gp inhibitor 14 (Compound 8a) is a high affinity P-gp inhibitor. P-gp inhibitor 14 reverses P-gp-mediated multidrug resistance (EC50=48.74 nM). P-gp inhibitor 14 has a weak inhibitory effect on CYP3A4 activity[1].

Name	P-gp inhibitor 14

Description	P-gp inhibitor 14 (Compound 8a) is a high affinity P-gp inhibitor. P-gp inhibitor 14 reverses P-gp-mediated multidrug resistance (EC50=48.74 nM). P-gp inhibitor 14 has a weak inhibitory effect on CYP3A4 activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Membrane Transporter/Ion Channel >> P-glycoprotein
References	[1]. Jiang C, et al. Design and evaluation of dibenzoazepine-tetrahydroisoquinoline hybrids as potential P-glycoprotein inhibitors against multidrug resistant K562/A02 cells. Eur J Med Chem. 2023 Mar 5;249:115150.

Molecular Formula	C₃₇H₃₈N₂O₈
Molecular Weight	638.71

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