CB 300919

Modify Date: 2025-08-26 16:48:59

CB 300919 structure	Common Name	CB 300919
	CAS Number	289715-28-2	Molecular Weight	584.11100
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₂H₃₄ClN₇O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of CB 300919

CB 300919 is a water-soluble analogue of CB30865; has a continuous exposure (96 h) growth inhibition IC50 value of 2 nM in human CH1 ovarian tumor xenograft.IC50 value:Target: Nampt

Name	4-[[7-chloro-3-methyl-2-[(4-methylpiperazin-1-yl)methyl]-4-oxoquinazolin-6-yl]methyl-prop-2-ynylamino]-N-(pyridin-3-ylmethyl)benzamide
Synonym	More Synonyms

Description	CB 300919 is a water-soluble analogue of CB30865; has a continuous exposure (96 h) growth inhibition IC50 value of 2 nM in human CH1 ovarian tumor xenograft.IC50 value:Target: Nampt
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Nampt Research Areas >> Cancer
References	[1]. Lockman JW, et al. Analogues of 4-[(7-Bromo-2-methyl-4-oxo-3H-quinazolin-6-yl)methylprop-2-ynylamino]-N-(3-pyridylmethyl)benzamide (CB-30865) as Potent Inhibitors of Nicotinamide Phosphoribosyltransferase (Nampt). J. Med. Chem., 2010, 53 (24), pp 8734-87 [2]. Bavetsias, V. et al. The Design and Synthesis of Water-Soluble Analogues of CB30865, a Quinazolin-4-one-Based Antitumor Agent. Journal of Medicinal Chemistry (2002), 45(17), 3692-3702.

Description

CB 300919 is a water-soluble analogue of CB30865; has a continuous exposure (96 h) growth inhibition IC50 value of 2 nM in human CH1 ovarian tumor xenograft.IC50 value:Target: Nampt

Related Catalog

Signaling Pathways >> Metabolic Enzyme/Protease >> Nampt

Research Areas >> Cancer

References

[1]. Lockman JW, et al. Analogues of 4-[(7-Bromo-2-methyl-4-oxo-3H-quinazolin-6-yl)methylprop-2-ynylamino]-N-(3-pyridylmethyl)benzamide (CB-30865) as Potent Inhibitors of Nicotinamide Phosphoribosyltransferase (Nampt). J. Med. Chem., 2010, 53 (24), pp 8734-87

[2]. Bavetsias, V. et al. The Design and Synthesis of Water-Soluble Analogues of CB30865, a Quinazolin-4-one-Based Antitumor Agent. Journal of Medicinal Chemistry (2002), 45(17), 3692-3702.

Molecular Formula	C₃₂H₃₄ClN₇O₂
Molecular Weight	584.11100
Exact Mass	583.24600
PSA	86.60000
LogP	3.56580
InChIKey	LWTCFUSGPRGUBX-UHFFFAOYSA-N
SMILES	C#CCN(Cc1cc2c(=O)n(C)c(CN3CCN(C)CC3)nc2cc1Cl)c1ccc(C(=O)NCc2cccnc2)cc1
Storage condition	2-8℃

Precursor 8
CAS#:3731-52-0 Picolamine CAS#:289686-90-4 tert-butyl 4-[N... CAS#:95-74-9 2-Chloro-4-amin... CAS#:7149-79-3 N-Acetyl-3-chlo...
CAS#:102170-52-5 2-Bromo-5-chlor... CAS#:116010-06-1 N-Acetyl 2-brom... CAS#:155184-81-9 2-Amino-4-chlor... CAS#:289686-80-2 2-AMINO-4-CHLOR...
DownStream 0

Name: Cytotoxicity against human HCT116 cells after 72 hrs
Source: ChEMBL
Target: HCT-116
External Id: CHEMBL1805769

Name: Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (...
Source: NCGC
External Id: IP6K1-p1

Name: Inhibition of Nampt activity in H2O2-induced DNA damage in human MCF10A cells stably ...
Source: ChEMBL
Target: Nicotinamide phosphoribosyltransferase
External Id: CHEMBL1805773

Name: Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu...
Source: NCGC
External Id: CYP3A4437

Name: Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu...
Source: NCGC
External Id: CYP2D6395

Name: Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu...
Source: NCGC
External Id: CYP2C9536

Name: qHTS for characterization and localization of zebrafish homologs of the human ABCB1 m...
Source: NCGC
External Id: mdr-f13-MDR19

Name: qHTS for characterization and localization of zebrafish homologs of the human ABCB1 m...
Source: NCGC
External Id: mdr-f13-ABCB4

Name: Inhibition of nicotinamide phosphoribosyltransferase-catalyzed conversion of nicotina...
Source: ChEMBL
Target: Nicotinamide phosphoribosyltransferase
External Id: CHEMBL1805766

Name: qHTS for characterization and localization of zebrafish homologs of the human ABCB1 m...
Source: NCGC
External Id: mdr-f13-ABCB5

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4-[N-[7-chloro-3-methyl-2-(4-methyl-piperazin-1-yl)methyl-4-oxo-3,4-dihydroquinazolin-6-ylmethyl]-N-(prop-2-ynyl)amino]-N-(pyridin-3-ylmethyl)benzamide

CS-0523

UNII-55I8ETE76Y

4-[N-[7-chloro-3-methyl-2-(4-methyl-piperazin-1-yl)methyl-4-oxo-3,4-dihydroquinazolin-6-ylmethyl]-N-(prop-2-ynyl)amino]-N-(3-pyridylmethyl)benzamide

CB 300919

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China
Product Name: CB300919
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: CB 300919
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Price: $388/10mM*1mLinDMSO

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CB 300919

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.