Netupitant

Modify Date: 2024-01-07 20:53:59

Netupitant structure	Common Name	Netupitant
	CAS Number	290297-26-6	Molecular Weight	578.592
	Density	1.3±0.1 g/cm3	Boiling Point	597.4±50.0 °C at 760 mmHg
	Molecular Formula	C₃₀H₃₂F₆N₄O	Melting Point	N/A
	MSDS	N/A	Flash Point	315.1±30.1 °C

Use of Netupitant

Netupitant (CID-6451149) is a highly potent and selective, orally active neurokinin-1 receptor antagonist with Ki of 0.95 nM.IC50 value: 0.95 nM (Ki) [1]Target: NK1 receptorin vitro: Netupitant also dose-dependently inhibited the SP response as expected from an NK1 receptor antagonist. Importantly, when both palonosetron and netupitant were present, they exhibited an enhanced inhibition of the SP response compared to either of the two antagonists alone [2].in vivo: In mice the intrathecal injection of SP elicited the typical scratching, biting and licking response that was dose-dependently inhibited by Netupitant given intraperitoneally in the 1-10mg/kg dose range. In gerbils, foot tapping behavior evoked by the intracerebroventricular injection of a NK(1) agonist was dose-dependently counteracted by Netupitant given intraperitoneally (ID(50) 1.5mg/kg) or orally (ID(50) 0.5mg/kg) [3].

Name	netupitant
Synonym	More Synonyms

Description	Netupitant (CID-6451149) is a highly potent and selective, orally active neurokinin-1 receptor antagonist with Ki of 0.95 nM.IC50 value: 0.95 nM (Ki) [1]Target: NK1 receptorin vitro: Netupitant also dose-dependently inhibited the SP response as expected from an NK1 receptor antagonist. Importantly, when both palonosetron and netupitant were present, they exhibited an enhanced inhibition of the SP response compared to either of the two antagonists alone [2].in vivo: In mice the intrathecal injection of SP elicited the typical scratching, biting and licking response that was dose-dependently inhibited by Netupitant given intraperitoneally in the 1-10mg/kg dose range. In gerbils, foot tapping behavior evoked by the intracerebroventricular injection of a NK(1) agonist was dose-dependently counteracted by Netupitant given intraperitoneally (ID(50) 1.5mg/kg) or orally (ID(50) 0.5mg/kg) [3].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor Research Areas >> Neurological Disease
References	[1]. Hoffmann T, et al. Design and synthesis of a novel, achiral class of highly potent and selective, orally active neurokinin-1 receptor antagonists. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1362-5. [2]. Stathis M, et al. Inhibition of substance P-mediated responses in NG108-15 cells by netupitant and palonosetron exhibit synergistic effects. Eur J Pharmacol. 2012 Aug 15;689(1-3):25-30. [3]. Rizzi A, et al. In vitro and in vivo pharmacological characterization of the novel NK1 receptor selective antagonist Netupitant. Peptides. 2012 Sep;37(1):86-97. [4]. Ajit G. Thomas, et al. Netupitant and palonosetron trigger NK1 receptor internalization in NG108-15 cells. Exp Brain Res. 2014; 232(8): 2637–2644.

Description

Related Catalog

Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor

Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor

Research Areas >> Neurological Disease

References

[1]. Hoffmann T, et al. Design and synthesis of a novel, achiral class of highly potent and selective, orally active neurokinin-1 receptor antagonists. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1362-5.

[2]. Stathis M, et al. Inhibition of substance P-mediated responses in NG108-15 cells by netupitant and palonosetron exhibit synergistic effects. Eur J Pharmacol. 2012 Aug 15;689(1-3):25-30.

[3]. Rizzi A, et al. In vitro and in vivo pharmacological characterization of the novel NK1 receptor selective antagonist Netupitant. Peptides. 2012 Sep;37(1):86-97.

[4]. Ajit G. Thomas, et al. Netupitant and palonosetron trigger NK1 receptor internalization in NG108-15 cells. Exp Brain Res. 2014; 232(8): 2637–2644.

Density	1.3±0.1 g/cm3
Boiling Point	597.4±50.0 °C at 760 mmHg
Molecular Formula	C₃₀H₃₂F₆N₄O
Molecular Weight	578.592
Flash Point	315.1±30.1 °C
Exact Mass	578.248047
PSA	39.68000
LogP	6.39
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.540
Storage condition	-20℃

Precursor 10
CAS#:290297-25-5 N-methyl-6-(4-m... CAS#:289686-69-7 α,α-dimethyl-3,... CAS#:342417-01-0 6-(4-Methylpipe... CAS#:342417-02-1 [6-(4-methyl-pi...
CAS#:109-01-3 methylpiperazine CAS#:4548-45-2 2-Chloro-5-nitr... CAS#:55403-34-4 1-Methyl-4-(5-n... CAS#:342417-00-9 6-chloro-4-o-to...
CAS#:342416-99-3 6-chloro-4-o-to... CAS#:342417-04-3 N-tert-butyl-6-...
DownStream 0