TRK-IN-23

Modify Date: 2025-08-29 21:21:10

TRK-IN-23 structure	Common Name	TRK-IN-23
	CAS Number	2924344-29-4	Molecular Weight	364.37
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₁₇FN₄O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of TRK-IN-23

TRK-IN-23 (compound 24b) is a potent and orally active TRK inhibitor with IC50 values of 0.5 nM, 9 nM, 14 nM, 4.4 nM, and 4.8 nM against TRKA, TRKC, TRKAG595R, TRKAF589L, and TRKAG667C, respectively. TRK-IN-23 indues apoptosis of Ba/F3-TRKAG595Rand Ba/F3-TRKAG667C cells[1].

Name	TRK-IN-23

Description	TRK-IN-23 (compound 24b) is a potent and orally active TRK inhibitor with IC50 values of 0.5 nM, 9 nM, 14 nM, 4.4 nM, and 4.8 nM against TRKA, TRKC, TRKAG595R, TRKAF589L, and TRKAG667C, respectively. TRK-IN-23 indues apoptosis of Ba/F3-TRKAG595Rand Ba/F3-TRKAG667C cells[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Trk Receptor
Target	TrkA:0.5 nM (IC50) TrkC:9 nM (IC50) TRKAG595R:14 nM (IC50) TRKAF589L:4.4 nM (IC50) TRKAG667C:4.8 nM (IC50)
References	[1]. Qiaohua Qin, et al. Design, synthesis and biological evaluation of novel indolin-2-one derivatives as potent second-generation TRKs inhibitors. Eur J Med Chem. 2023 May 5;253:115291.

Molecular Formula	C₂₀H₁₇FN₄O₂
Molecular Weight	364.37

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TRK-IN-23

Use of TRK-IN-23

Names

TRK-IN-23 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.