SIKs-IN-1

Modify Date: 2025-09-15 17:38:30

SIKs-IN-1 Structure
SIKs-IN-1 structure
 Common Name SIKs-IN-1
CAS Number 2927557-06-8 Molecular Weight 507.58
Density N/A Boiling Point N/A
Molecular Formula C27H31F2N7O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of SIKs-IN-1


SIKs-IN-1 (compound 8h), a pyrimidine-5-carboxamide derivative, is a Salt-inducible kinases (SIKs) inhibitor. SIKs regulates the transformation of M1/M2 macrophages, involving in inflammation process. SIKs-IN-1 inhibits SIK activity, up-regulates anti-inflammatory cytokine IL-10, but down-regulates pro-inflammatory cytokine IL-12. SIKs-IN-1 shows excellent anti-inflammatory effects in a DSS-induced colitis model[1].

 Names

Name SIKs-IN-1

 SIKs-IN-1 Biological Activity

Description SIKs-IN-1 (compound 8h), a pyrimidine-5-carboxamide derivative, is a Salt-inducible kinases (SIKs) inhibitor. SIKs regulates the transformation of M1/M2 macrophages, involving in inflammation process. SIKs-IN-1 inhibits SIK activity, up-regulates anti-inflammatory cytokine IL-10, but down-regulates pro-inflammatory cytokine IL-12. SIKs-IN-1 shows excellent anti-inflammatory effects in a DSS-induced colitis model[1].
Related Catalog
References

[1]. Cai X, et al. Discovery of pyrimidine-5-carboxamide derivatives as novel salt-inducible kinases (SIKs) inhibitors for inflammatory bowel disease (IBD) treatment. Eur J Med Chem. 2023 Aug 5;256:115469.  

 Chemical & Physical Properties

Molecular Formula C27H31F2N7O
Molecular Weight 507.58
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Chemsrc provides SIKs-IN-1(CAS#:2927557-06-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of SIKs-IN-1 are included as well.>> amp version: SIKs-IN-1

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