HP661

Modify Date: 2025-08-25 13:05:36

HP661 Structure
HP661 structure
Common Name HP661
CAS Number 2938220-60-9 Molecular Weight 661.60
Density N/A Boiling Point N/A
Molecular Formula C31H29F6N7O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of HP661


HP661 is an orally available oxidative phosphorylation (OXPHOS) inhibitor that effectively blocks the activity of mitochondrial complex I and reduces the production of the reactive oxygen species. HP661 can abrogate the growth of high OXPHOS-dependent tumors, conquer high OXPHOS-mediated drug resistance, and can induce cell apoptosis. And HP661 can be used for anti-tumor research[1].

 Names

Name HP661

 HP661 Biological Activity

Description HP661 is an orally available oxidative phosphorylation (OXPHOS) inhibitor that effectively blocks the activity of mitochondrial complex I and reduces the production of the reactive oxygen species. HP661 can abrogate the growth of high OXPHOS-dependent tumors, conquer high OXPHOS-mediated drug resistance, and can induce cell apoptosis. And HP661 can be used for anti-tumor research[1].
Related Catalog
References

[1]. He P, et.al. Discovery of a Potent and Oral Available Complex I OXPHOS Inhibitor That Abrogates Tumor Growth and Circumvents MEKi Resistance. J Med Chem. 2023 May 11;66(9):6047-6069.  

 Chemical & Physical Properties

Molecular Formula C31H29F6N7O3
Molecular Weight 661.60
InChIKey ZMBFFBOMUBIJGL-UHFFFAOYSA-N
SMILES Cc1c(C(=O)N2CCN(Cc3ccc(OCC(F)(F)F)cc3)CC2)nnn1Cc1ccc(C(=O)Nc2ccc(C(F)(F)F)cc2)nc1
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.