Ranatensin

Modify Date: 2024-01-05 00:52:28

Ranatensin structure	Common Name	Ranatensin
	CAS Number	29451-71-6	Molecular Weight	1281.48000
	Density	1.326 g/cm3	Boiling Point	1790.5ºC at 760 mmHg
	Molecular Formula	C₆₁H₈₄N₁₆O₁₃S	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	1036.6ºC

Use of Ranatensin

Ranatensin is a undecapeptide and a Bombesin Receptor angonist, can be isolated from amphibian skin, such as the frog, Rana pipiens. Ranatensin could maintain the dynamic balance of animal blood pressure, without cross-tachyphylaxis with Angiotensin amide (HY-P2212), Bradykinin (HY-P0206), or Norepinephrine (HY-13715)[1][2].

Name	ranatensin
Synonym	More Synonyms

Description	Ranatensin is a undecapeptide and a Bombesin Receptor angonist, can be isolated from amphibian skin, such as the frog, Rana pipiens. Ranatensin could maintain the dynamic balance of animal blood pressure, without cross-tachyphylaxis with Angiotensin amide (HY-P2212), Bradykinin (HY-P0206), or Norepinephrine (HY-13715)[1][2].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> Bombesin Receptor
In Vitro	Ranatensin (0.3 nM; 30 min) 能够刺激多种胰促分泌物诱导淀粉酶释放[1]。
In Vivo	Ranatesin (10-50 μg/mL, 0.1-1 mL; 静脉注射; 单剂量) 会增加狗和兔子的血压，表明其具有直接的外周血管收缩作用[2]。 Ranatesin (10-50 μg/mL, 0.1-1 mL; 静脉注射; 单剂量) 也能降低猴子的血压，与 Eledoisin (HY-P0006) 一样有效。它对血管平滑肌有直接的外周作用[2]。 Ranatesin (10-50 μg/mL, 0.005-0.1 mL; 静脉注射; 单剂量) 根据大鼠血压的基础水平具有可变的作用，在高水平时显示出降压效果，在低水平时升高血压，产生这一变化的可能原因是外周交感神经末梢释放去甲肾上腺素[2]。
References	[1]. Jensen RT, et al. A synthetic peptide that is a bombesin receptor antagonist. Nature. 1984 May 3-9;309(5963):61-3. [2]. Geller RG, et al. The action of ranatensin, a new polypeptide from amphibian skin, on the blood pressure of experimental animals. Br J Pharmacol. 1970 Dec;40(4):605-16.

Density	1.326 g/cm3
Boiling Point	1790.5ºC at 760 mmHg
Molecular Formula	C₆₁H₈₄N₁₆O₁₃S
Molecular Weight	1281.48000
Flash Point	1036.6ºC
Exact Mass	1280.61000
PSA	467.26000
LogP	3.20430
Vapour Pressure	0mmHg at 25°C
Index of Refraction	1.607
Storage condition	−20°C

Ranatensin MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3

Molecular biology of bombesin-like peptides. Comparison of cDNAs encoding human gastrin-releasing peptide, human neuromedin B, and amphibian ranatensin.

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To examine the biochemical basis for growth factor-induced responses in human lung cancer cells, we used the quin2 technique to study the effect of the amphibian peptide bombesin and its congeners inc...

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The combination method of carboxypeptidase Y digestion and fast atom bombardment (FAB) mass spectrometry is described for the identification of C-terminal amino acid amides in peptides. Carboxypeptida...

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