Bentazepam

Modify Date: 2024-01-07 15:21:06

Bentazepam structure	Common Name	Bentazepam
	CAS Number	29462-18-8	Molecular Weight	296.38700
	Density	1.38g/cm3	Boiling Point	532.6ºC at 760 mmHg
	Molecular Formula	C₁₇H₁₆N₂OS	Melting Point	N/A
	MSDS	N/A	Flash Point	275.9ºC

Use of Bentazepam

Bentazepam (Thiadipone) is a compound with short-action anxiolytic effect. Bentazepam shows anticonvulsant and sedative properties. Bentazepam can be used for the research of depressive disorder and anxiety[1].

Name	5-phenyl-3,4,6,7,8,9-hexahydro-[1]benzothiolo[2,3-e][1,4]diazepin-2-one
Synonym	More Synonyms

Description	Bentazepam (Thiadipone) is a compound with short-action anxiolytic effect. Bentazepam shows anticonvulsant and sedative properties. Bentazepam can be used for the research of depressive disorder and anxiety[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vivo	Bentazepam increases the anticonvulsive activity of clonazepam[1].

Density	1.38g/cm3
Boiling Point	532.6ºC at 760 mmHg
Molecular Formula	C₁₇H₁₆N₂OS
Molecular Weight	296.38700
Flash Point	275.9ºC
Exact Mass	296.09800
PSA	69.70000
LogP	2.99000
Vapour Pressure	2E-11mmHg at 25°C
Index of Refraction	1.733

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DL8230000

CHEMICAL NAME :: 2H-(1)Benzothieno(2,3-e)-1,4-diazepin-2-one, 1,3,6,7,8,9-hexahydro-5-phenyl-

CAS REGISTRY NUMBER :: 29462-18-8

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C17-H16-N2-O-S

MOLECULAR WEIGHT :: 296.41

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 129 mg/kg/17W-I

TOXIC EFFECTS :: Behavioral - anorexia (human) Behavioral - muscle weakness Liver - liver function tests impaired

REFERENCE :: LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 343,860,1994

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,926,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 980 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,926,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 630 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,926,1975

N/A

CAS#:29462-27-9

Bentazepam

CAS#:29462-18-8

Literature: Tinney; Sanchez; Nogas Journal of Medicinal Chemistry, 1974 , vol. 17, # 6 p. 624 - 630

5,6,7,8-tetrahy...

CAS#:41042-86-8

Bentazepam

CAS#:29462-18-8

Literature: Nakanishi,M. et al. Journal of Medicinal Chemistry, 1973 , vol. 16, p. 214 - 219

(E)-3-amino-3-p...

CAS#:43215-25-4

Glycine ethyl e...

CAS#:623-33-6

Bentazepam

CAS#:29462-18-8

Literature: Heckendorn; Gagneux Tetrahedron Letters, 1973 , vol. 25, p. 2279 - 2282

Precursor 3
CAS#:41042-86-8 5,6,7,8-tetrahy... CAS#:43215-25-4 (E)-3-amino-3-p... CAS#:623-33-6 Glycine ethyl e...
DownStream 0

Bentazepam

CI-718

Tiadipone

Thiadipone

1,3,6,7,8,9-Hexahydro-5-phenyl-2H-(1)benzothieno(2,3-e)-1,4-diazepin-2-one

QM-6008

5-phenyl-1,3,6,7,8,9-hexahydro-benzo[4,5]thieno[2,3-e][1,4]diazepin-2-one

Bentazepamum [INN-Latin]

2H-(1)BENZOTHIENO(2,3-e)-1,4-DIAZEPIN-2-ONE,1,3,6,7,8,9-HEXAHYDRO-5-PHENYL

DC Chemicals Limited
China
Product Name: Bentazepam
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Bentazepam

Use of Bentazepam

Names

Bentazepam Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Synthetic Route

Precursor & DownStream

Synonyms