PI3Kα-IN-13

Modify Date: 2025-08-27 15:27:44

PI3Kα-IN-13 structure	Common Name	PI3Kα-IN-13
	CAS Number	2955529-67-4	Molecular Weight	389.41
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₁H₁₉N₅O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PI3Kα-IN-13

PI3Kα-IN-13 (Compound 18a) is a PI3Kα inhibitor (IC50: 2.5 nM). PI3Kα-IN-13 induces tumor cell apoptosis. PI3Kα-IN-13 inhibits cancer cell proliferation with IC50s of 0.75 μM (MCF-7), 3.79 μM (HCT-116), 13.71 μM (MDA-MB-231), 9.85 μM (SW620), respectively. PI3Kα-IN-13 inhibits tumor cell colony formation, migration and invasion[1].

Name	PI3Kα-IN-13

Description	PI3Kα-IN-13 (Compound 18a) is a PI3Kα inhibitor (IC50: 2.5 nM). PI3Kα-IN-13 induces tumor cell apoptosis. PI3Kα-IN-13 inhibits cancer cell proliferation with IC50s of 0.75 μM (MCF-7), 3.79 μM (HCT-116), 13.71 μM (MDA-MB-231), 9.85 μM (SW620), respectively. PI3Kα-IN-13 inhibits tumor cell colony formation, migration and invasion[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> PI3K
Target	PI3Kα
References	[1]. Zheng XM, et al. Design, synthesis and bioevaluation of PI3Kα-selective inhibitors as potential colorectal cancer drugs. Eur J Med Chem. 2023 Nov 15;260:115754.

Molecular Formula	C₂₁H₁₉N₅O₃
Molecular Weight	389.41
InChIKey	SPYYQFSRIJDCSR-KDURUIRLSA-N
SMILES	Nc1nc2cc(-c3ccc4ncc(N5CC6OCCOC6C5)nc4c3)ccc2o1

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PI3Kα-IN-13

Use of PI3Kα-IN-13

Names

PI3Kα-IN-13 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.