PI3Kα-IN-13

• 常用名: PI3Kα-IN-13
• 英文名: PI3Kα-IN-13
• CAS号: 2955529-67-4
• 分子量: 389.41
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₁H₁₉N₅O₃
• 熔点: N/A
• 闪点: N/A

PI3Kα-IN-13用途

PI3Kα-IN-13 (Compound 18a) 是一种 PI3Kα 抑制剂 (IC50: 2.5 nM)。PI3Kα-IN-13 诱导肿瘤细胞凋亡 (apoptosis)。PI3Kα-IN-13 抑制癌细胞增殖,IC50s 分别为 0.75 μM (MCF-7)、3.79 μM (HCT-116)、13.71 μM (MDA-MB) -231), 9.85 μM (SW620)。PI3Kα-IN-13 抑制肿瘤细胞集落形成、迁移和侵袭。

PI3Kα-IN-13名称

• 英文名: PI3Kα-IN-13

PI3Kα-IN-13生物活性

• 描述: PI3Kα-IN-13 (Compound 18a) 是一种 PI3Kα 抑制剂 (IC50: 2.5 nM)。PI3Kα-IN-13 诱导肿瘤细胞凋亡 (apoptosis)。PI3Kα-IN-13 抑制癌细胞增殖,IC50s 分别为 0.75 μM (MCF-7)、3.79 μM (HCT-116)、13.71 μM (MDA-MB) -231), 9.85 μM (SW620)。PI3Kα-IN-13 抑制肿瘤细胞集落形成、迁移和侵袭。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> PI3K/Akt/mTOR 信号通路 >> PI3K
• 靶点实验:

  PI3Kα

• 参考文献:

  [1]. Zheng XM, et al. Design, synthesis and bioevaluation of PI3Kα-selective inhibitors as potential colorectal cancer drugs. Eur J Med Chem. 2023 Nov 15;260:115754.

PI3Kα-IN-13物理化学性质

• 分子式: C₂₁H₁₉N₅O₃
• 分子量: 389.41
• InChIKey: SPYYQFSRIJDCSR-KDURUIRLSA-N
• SMILES: Nc1nc2cc(-c3ccc4ncc(N5CC6OCCOC6C5)nc4c3)ccc2o1

PI3Kα-IN-13靶点实验

查看更多实验

实验名称：Half life in Sprague-Dawley rat at 5 mg/kg, iv measured upto 24 hrs by LC-MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5635358

实验名称：Clearance in Sprague-Dawley rat at 5 mg/kg, iv measured upto 24 hrs by LC-MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5635359

实验名称：Volume of distribution in Sprague-Dawley rat at 5 mg/kg, iv measured upto 24 hrs by L... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5635360

实验名称：Inhibition of human FLT3 at 1 uM 来源：ChEMBL 靶标：Receptor-type tyrosine-protein kinase FLT3 External Id：CHEMBL5635362

实验名称：Inhibition of human FLT3 D835Y mutant at 1 uM 来源：ChEMBL 靶标：Receptor-type tyrosine-protein kinase FLT3 External Id：CHEMBL5635363

实验名称：Inhibition of human DRAK1 at 1 uM 来源：ChEMBL 靶标：Serine/threonine-protein kinase 17A External Id：CHEMBL5635364

实验名称：Antiproliferative activity against human A549 cells assessed as reduction in cell via... 来源：ChEMBL 靶标：A549 External Id：CHEMBL5635365

实验名称：Antiproliferative activity against human MKN-45 cells assessed as reduction in cell v... 来源：ChEMBL 靶标：MKN-45 External Id：CHEMBL5635366

实验名称：Antiproliferative activity against human HeLa cells assessed as reduction in cell via... 来源：ChEMBL 靶标：HeLa External Id：CHEMBL5635367

实验名称：Antiproliferative activity against human K562 cells assessed as reduction in cell via... 来源：ChEMBL 靶标：K562 External Id：CHEMBL5635368

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