N-Desmethyl Clomipramine Hydrochloride
Modify Date: 2024-01-31 14:42:20
N-Desmethyl Clomipramine Hydrochloride structure
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Common Name | N-Desmethyl Clomipramine Hydrochloride | ||
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| CAS Number | 29854-14-6 | Molecular Weight | 337.28700 | |
| Density | N/A | Boiling Point | 466ºC at 760 mmHg | |
| Molecular Formula | C18H22Cl2N2 | Melting Point | 204-206°C (dec.) | |
| MSDS | N/A | Flash Point | 235.6ºC | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
Use of N-Desmethyl Clomipramine HydrochlorideN-Desmethyl Clomipramine hydrochloride (Desmethylclomipramine hydrochloride) is a primary plasma N-desmethyl metabolite of Clomipramine. Clomipramine is a tricyclic antidepressant[1][2]. |
| Name | 3-(3-Chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-methyl-1- propanamine hydrochloride (1:1) |
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| Description | N-Desmethyl Clomipramine hydrochloride (Desmethylclomipramine hydrochloride) is a primary plasma N-desmethyl metabolite of Clomipramine. Clomipramine is a tricyclic antidepressant[1][2]. |
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| Related Catalog | |
| References |
| Boiling Point | 466ºC at 760 mmHg |
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| Melting Point | 204-206°C (dec.) |
| Molecular Formula | C18H22Cl2N2 |
| Molecular Weight | 337.28700 |
| Flash Point | 235.6ºC |
| Exact Mass | 336.11600 |
| PSA | 15.27000 |
| LogP | 5.44410 |
| Vapour Pressure | 4.41E-09mmHg at 25°C |
| Storage condition | -20°C Freezer |
| Symbol |
GHS02, GHS06, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H225-H301 + H311 + H331-H370 |
| Precautionary Statements | P210-P260-P280-P301 + P310-P311 |
| Hazard Codes | F,T |
| Risk Phrases | 11-23/24/25-39/23/24/25 |
| Safety Phrases | 7-16-36/37-45 |
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
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Steady state concentrations of clomipramine and its major metabolite desmethylclomipramine in rat brain and serum after oral administration of clomipramine.
Eur. Neuropsychopharmacol. 10(5) , 401-5, (2000) Twenty male Sprague-Dawley rats received five oral doses of clomipramine 20 mg/kg at 4-h intervals. The animals were decapitated 1, 2, 3, 5 and 12 h after the last dose for determination of clomiprami... |
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Clinical significance of plasma levels of clomipramine, its hydroxylated and desmethylated metabolites: prediction of clinical outcome in mood disorders using discriminant analysis of therapeutic drug monitoring data.
J. Affect. Disord. 29(4) , 267-79, (1993) We measured the plasma concentrations of clomipramine and its metabolites, N-desmethylclompiramine, 8-hydroxy-N-desmethylclomipramine, 8-hydroxyclomipramine in 65 depressed patients with subtypes of D... |
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Pharmacokinetics of clomipramine in dogs following single-dose and repeated-dose oral administration.
Am. J. Vet. Res. 61(1) , 80-5, (2000) To determine pharmacokinetics of clomipramine and its principle metabolite (desmethylclomipramine) in the plasma of dogs following single-dose and repeated-dose oral administration at various dosages.... |