CHEMICAL IDENTIFICATION
 - 
  RTECS NUMBER :
 
 
 - 
  MU7175000
 
 
 
 - 
  CHEMICAL NAME :
 
 
 - 
  Hydrazine
 
 
 
 - 
  CAS REGISTRY NUMBER :
 
 
 - 
  302-01-2
 
 
 
 - 
  LAST UPDATED :
 
 
 - 
  199712
 
 
 
 - 
  DATA ITEMS CITED :
 
 
 - 
  108
 
 
 
 - 
  MOLECULAR FORMULA :
 
 
 - 
  H4-N2
 
 
 
 - 
  MOLECULAR WEIGHT :
 
 
 - 
  32.06
 
 
 
 - 
  WISWESSER LINE NOTATION :
 
 
 - 
  ZZ
 
 
 
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
 - 
  TYPE OF TEST :
 
 
 - 
  LD50 - Lethal dose, 50 percent kill
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Oral
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Rodent - rat
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  60 mg/kg
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Details of toxic effects not reported other than lethal dose value
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  LC50 - Lethal concentration, 50 percent kill
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Inhalation
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Rodent - rat
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  570 ppm/4H
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  LD50 - Lethal dose, 50 percent kill
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Intraperitoneal
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Rodent - rat
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  59 mg/kg
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Details of toxic effects not reported other than lethal dose value
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  LD50 - Lethal dose, 50 percent kill
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Intravenous
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Rodent - rat
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  55 mg/kg
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Details of toxic effects not reported other than lethal dose value
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  LD50 - Lethal dose, 50 percent kill
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Intramuscular
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Rodent - rat
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  53500 ug/kg
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Details of toxic effects not reported other than lethal dose value
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  LD50 - Lethal dose, 50 percent kill
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Oral
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Rodent - mouse
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  59 mg/kg
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Details of toxic effects not reported other than lethal dose value
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  LC50 - Lethal concentration, 50 percent kill
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Inhalation
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Rodent - mouse
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  252 ppm/4H
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  LD50 - Lethal dose, 50 percent kill
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Intraperitoneal
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Rodent - mouse
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  62 mg/kg
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Details of toxic effects not reported other than lethal dose value
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  LD50 - Lethal dose, 50 percent kill
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Intravenous
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Rodent - mouse
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  57 mg/kg
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Details of toxic effects not reported other than lethal dose value
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  LD50 - Lethal dose, 50 percent kill
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Unreported
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Rodent - mouse
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  200 mg/kg
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Details of toxic effects not reported other than lethal dose value
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  LDLo - Lowest published lethal dose
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Administration onto the skin
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Mammal - dog
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  96 mg/kg
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Details of toxic effects not reported other than lethal dose value
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  LD50 - Lethal dose, 50 percent kill
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Intravenous
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Mammal - dog
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  25 mg/kg
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Details of toxic effects not reported other than lethal dose value
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  LD50 - Lethal dose, 50 percent kill
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Intramuscular
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Mammal - dog
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  16500 ug/kg
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Details of toxic effects not reported other than lethal dose value
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  LD50 - Lethal dose, 50 percent kill
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Administration onto the skin
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Rodent - rabbit
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  91 mg/kg
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Details of toxic effects not reported other than lethal dose value
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  LD50 - Lethal dose, 50 percent kill
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Intravenous
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Rodent - rabbit
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  20 mg/kg
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Details of toxic effects not reported other than lethal dose value
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  LD50 - Lethal dose, 50 percent kill
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Intramuscular
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Rodent - rabbit
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  38500 ug/kg
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Details of toxic effects not reported other than lethal dose value
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  LD50 - Lethal dose, 50 percent kill
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Administration onto the skin
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Rodent - guinea pig
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  190 mg/kg
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Behavioral - convulsions or effect on seizure threshold
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TCLo - Lowest published toxic concentration
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Inhalation
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Rodent - rat
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  1 ppm/24H/90D-C
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Related to Chronic Data - death
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TCLo - Lowest published toxic concentration
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Inhalation
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Rodent - rat
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  5 ppm/6H/26W-I
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Behavioral - muscle weakness Related to Chronic Data - death
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TCLo - Lowest published toxic concentration
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Inhalation
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Rodent - rat
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  10 mg/m3/4H/30D-I
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Liver - liver function tests impaired Kidney, Ureter, Bladder - other changes in urine composition Blood - changes in bone marrow (not otherwise specified)
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TCLo - Lowest published toxic concentration
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Inhalation
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Rodent - mouse
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  1 ppm/24H/90D-C
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Related to Chronic Data - death
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TCLo - Lowest published toxic concentration
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Inhalation
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Rodent - mouse
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  14 ppm/6H/5W-I
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Related to Chronic Data - death
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TCLo - Lowest published toxic concentration
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Inhalation
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Mammal - dog
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  14 ppm/6H/26W-I
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Behavioral - food intake (animal) Behavioral - muscle weakness Related to Chronic Data - death
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TCLo - Lowest published toxic concentration
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Inhalation
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Primate - monkey
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  1 ppm/24H/90D-C
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Related to Chronic Data - death
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TCLo - Lowest published toxic concentration
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Inhalation
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Rodent - guinea pig
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  14 ppm/6H/14W-I
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Related to Chronic Data - death
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TCLo - Lowest published toxic concentration
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Inhalation
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Rodent - hamster
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  1 ppm/6H/1Y-I
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Liver - other changes Kidney, Ureter, Bladder - other changes Endocrine - other changes
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TDLo - Lowest published toxic dose
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Oral
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Rodent - rat
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  900 mg/kg/2Y-C
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Tumorigenic - neoplastic by RTECS criteria Liver - tumors
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TCLo - Lowest published toxic concentration
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Inhalation
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Rodent - rat
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  5 ppm/6H/1Y-I
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Tumorigenic - Carcinogenic by RTECS criteria Endocrine - thyroid tumors
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TDLo - Lowest published toxic dose
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Oral
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Rodent - mouse
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  1951 mg/kg/2Y-C
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - lymphoma, including Hodgkin's disease
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TCLo - Lowest published toxic concentration
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Inhalation
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Rodent - mouse
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  1 ppm/6H/1Y-I
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TDLo - Lowest published toxic dose
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Intraperitoneal
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Rodent - mouse
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  400 mg/kg/5W-I
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Tumorigenic - Carcinogenic by RTECS criteria Blood - tumors Blood - leukemia
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TCLo - Lowest published toxic concentration
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Inhalation
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Rodent - hamster
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  1 ppm/6H/1Y-I
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - colon tumors
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TC - Toxic concentration (other than lowest)
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Inhalation
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Rodent - rat
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  5 ppm/6H/1Y-I
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TC - Toxic concentration (other than lowest)
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Inhalation
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Rodent - rat
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  1 ppm/6H/1Y-I
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TC - Toxic concentration (other than lowest)
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Inhalation
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Rodent - hamster
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  5 ppm/6H/1Y-I
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TCLo - Lowest published toxic concentration
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Inhalation
 
 
 
 - 
  DOSE :
 
 
 - 
  4 mg/m3/2H
 
 
 
 - 
  SEX/DURATION :
 
 
 - 
  female 7-20 day(s) after conception
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TCLo - Lowest published toxic concentration
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Inhalation
 
 
 
 - 
  DOSE :
 
 
 - 
  1 mg/m3/24H
 
 
 
 - 
  SEX/DURATION :
 
 
 - 
  female 1-11 day(s) after conception
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TDLo - Lowest published toxic dose
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Administration onto the skin
 
 
 
 - 
  DOSE :
 
 
 - 
  50 mg/kg
 
 
 
 - 
  SEX/DURATION :
 
 
 - 
  female 9 day(s) after conception
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TDLo - Lowest published toxic dose
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Intraperitoneal
 
 
 
 - 
  DOSE :
 
 
 - 
  100 mg/kg
 
 
 
 - 
  SEX/DURATION :
 
 
 - 
  female 6-15 day(s) after conception
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TDLo - Lowest published toxic dose
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Intraperitoneal
 
 
 
 - 
  DOSE :
 
 
 - 
  50 mg/kg
 
 
 
 - 
  SEX/DURATION :
 
 
 - 
  female 6-15 day(s) after conception
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TDLo - Lowest published toxic dose
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Intraperitoneal
 
 
 
 - 
  DOSE :
 
 
 - 
  30 mg/kg
 
 
 
 - 
  SEX/DURATION :
 
 
 - 
  female 7-9 day(s) after conception
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - urogenital system
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TDLo - Lowest published toxic dose
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Intraperitoneal
 
 
 
 - 
  DOSE :
 
 
 - 
  30 mg/kg
 
 
 
 - 
  SEX/DURATION :
 
 
 - 
  female 7-9 day(s) after conception
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TDLo - Lowest published toxic dose
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Subcutaneous
 
 
 
 - 
  DOSE :
 
 
 - 
  80 mg/kg
 
 
 
 - 
  SEX/DURATION :
 
 
 - 
  female 11-20 day(s) after conception
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TDLo - Lowest published toxic dose
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Intraperitoneal
 
 
 
 - 
  DOSE :
 
 
 - 
  48 mg/kg
 
 
 
 - 
  SEX/DURATION :
 
 
 - 
  female 6-9 day(s) after conception
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TDLo - Lowest published toxic dose
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Intraperitoneal
 
 
 
 - 
  DOSE :
 
 
 - 
  80 mg/kg
 
 
 
 - 
  SEX/DURATION :
 
 
 - 
  female 6-9 day(s) after conception
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - urogenital system
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TCLo - Lowest published toxic concentration
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Inhalation
 
 
 
 - 
  DOSE :
 
 
 - 
  1 ppm/6H
 
 
 
 - 
  SEX/DURATION :
 
 
 - 
  male 1 year(s) pre-mating
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Reproductive - Paternal Effects - testes, epididymis, sperm duct
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  Sex chromosome loss and nondisjunction
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  Unscheduled DNA synthesis
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  DNA inhibition
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  DNA inhibition
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  DNA damage
 
 
 
MUTATION DATA
 - 
  TYPE OF TEST :
 
 
 - 
  DNA damage
 
 
 
 - 
  TEST SYSTEM :
 
 
 - 
  Mammal - species unspecified Lymphocyte
 
 
 
 - 
  REFERENCE :
 
 
 - 
  BBACAQ Biochimica et Biophysica Acta. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1947- Volume(issue)/page/year: 174,591,1969 *** REVIEWS *** ACGIH TLV-Animal carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 0.013 mg/m3 (0.01 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 4,127,1974 IARC Cancer Review:Human Inadequate Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,223,1987 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,223,1987 TOXICOLOGY REVIEW AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. Volume(issue)/page/year: 9,199,1954 TOXICOLOGY REVIEW ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN. Volume(issue)/page/year: 28,135,1971 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 1 ppm (1.3 mg/m3) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,127,1971 OSHA PEL (Gen Indu):8H TWA 1 ppm (1.3 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 1 ppm (1.3 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 1 ppm (1.3 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 1 ppm (1.3 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.1 ppm (0.1 mg/m3);Skin;Carcinogen JAN 1993 OEL-DENMARK:TWA 0.1 ppm (0.13 mg/m3);Skin;Carcinogen JAN 1993 OEL-FINLAND:TWA 0.1 ppm (0.13 mg/m3);STEL 0.3 ppm (0.4 mg/m3);Skin;Carcinogen JAN 1993 OEL-FRANCE:TWA 0.1 ppm (0.1 mg/m3);Carcinogen JAN 1993 OEL-GERMANY;Skin;Carcinogen JAN 1993 OEL-THE NETHERLANDS:TWA 0.1 ppm (0.13 mg/m3);Skin JAN 1993 OEL-THE PHILIPPINES:TWA 1 ppm (1.3 mg/m3);Skin JAN 1993 OEL-RUSSIA:STEL 0.1 mg/m3;Skin JAN 1993 OEL-SWEDEN:TWA 0.1 ppm (0.1 mg/m3);STEL 0.3 ppm (0.4 mg/m3);Skin;Carcinogen JAN 1993 OEL-SWITZERLAND:TWA 0.1 ppm (0.13 mg/m3);Skin;Carcinogen JAN 1993 OEL-TURKEY:TWA 1 ppm (1.3 mg/m3);Skin JAN 1993 OEL-UNITED KINGDOM;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO HYDRAZINES-air:CA CL 0.03 ppm/120M REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 38110 No. of Facilities: 2134 (estimated) No. of Industries: 37 No. of Occupations: 27 No. of Employees: 11185 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 38110 No. of Facilities: 2515 (estimated) No. of Industries: 44 No. of Occupations: 46 No. of Employees: 60490 (estimated) No. of Female Employees: 2841 (estimated)
 
 
  
                                        
                                     
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