Succimer
Succimer structure
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Common Name | Succimer | ||
|---|---|---|---|---|
| CAS Number | 304-55-2 | Molecular Weight | 182.218 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 267.6±40.0 °C at 760 mmHg | |
| Molecular Formula | C4H6O4S2 | Melting Point | 196-198ºC (dec.) | |
| MSDS | Chinese USA | Flash Point | 115.6±27.3 °C | |
Use of SuccimerSuccimer is a widely used chelating agent for the treatment of Pb poisoning. |
Summary: succimer, also known as 2,3-dimercaptopropanesulfonic acid, has a CAS number of 304-55-2, with a molecular formula of C4H6O4S2 and a molecular weight of 182.218. It is a white crystalline powder, with a melting point of 196-198℃ (decomposition) and a boiling point of 267.6±40.0 °C, and a density of 1.6±0.1 g/cm3. For research-use only, not for medical or clinical usage.
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | succimer |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Succimer is a widely used chelating agent for the treatment of Pb poisoning. |
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| Related Catalog | |
| In Vivo | Succimer is a widely used chelating agent for the treatment of Pb poisoning. Red blood cells (RBCs) from lead exposed animals treated with NAC or Succimer are shown to have significantly higher glutathione (GSH) levels and diminished malondialdehyde (MDA) levels when compare to the lead group. Succimer administration also results in decreased glucose 6-phosphate dehydrogenase (G6PD) activity in RBCs from lead exposed animals[1]. Succimer treatment produces a significant reduction in blood lead levels for both lead exposure conditions: the High Pb-succ group has blood lead levels that are 27% of the blood lead levels of the High Pb group at the end of treatment. Succimer is effective in substantially reducing brain lead, as brain lead levels in the High Pb-succ group are 37% of levels in the High Pb group[2]. |
| Animal Admin | All experiments are performed with Fisher 344 male rats weighing 75 to 100 g. The animals are randomized into four groups. Group I (n=11) serves as the control and is given only standard rat chow and water for 6 weeks. Group II (n=11) receives 2000 ppm lead acetate in its drinking water for 5 weeks and, during the 6th week, this group receives water. Group III (n=6) receives 2000 ppm lead acetate in its drinking water for 5 weeks and, during the 6th week, these animals receive 800 mg/kg/day NAC dissolved in water. Group IV (n=6) is treated like group III, except that it receives 90 mg/kg/day Succimer during the last week. At the end of the 6th week, after overnight fasting, the animals are anesthetized with metofane and blood samples are collected via intracardiac puncture using heparin as an anticoagulant. Plasma and the buffy coat are removed by centrifugation for 10 min at 3000 rpm. The RBCs are washed three times with an equal volume of cold saline[1]. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 267.6±40.0 °C at 760 mmHg |
| Melting Point | 196-198ºC (dec.) |
| Molecular Formula | C4H6O4S2 |
| Molecular Weight | 182.218 |
| Flash Point | 115.6±27.3 °C |
| Exact Mass | 181.970749 |
| PSA | 152.20000 |
| LogP | 1.93 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.617 |
| InChIKey | ACTRVOBWPAIOHC-XIXRPRMCSA-N |
| SMILES | O=C(O)C(S)C(S)C(=O)O |
| Storage condition | −20°C |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38 |
| Safety Phrases | 24/25-26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 2 |
| RTECS | WM7650000 |
| HS Code | 2930909090 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
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Succimer CAS#:304-55-2 |
| Literature: Helvetica Chimica Acta, , vol. 44, p. 955 - 960 |
This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2930909090 |
|---|---|
| Summary | 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
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A novel pathway producing dimethylsulphide in bacteria is widespread in soil environments.
Nat. Commun. 6 , 6579, (2015) The volatile compound dimethylsulphide (DMS) is important in climate regulation, the sulphur cycle and signalling to higher organisms. Microbial catabolism of the marine osmolyte dimethylsulphonioprop... |
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Identification and Characterization of EDTA Test Strip Interfering Substances Using a Digital Color Detector.
Clin. Lab. 61 , 785-91, (2015) Rapid test strips for ethylenediaminetetraacetic acid (EDTA) can be used to verify correct specimen types for clinical assays which require, or cannot be performed on, plasma collection tubes containi... |
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How do esters and dimethyl sulphide concentrations affect fruity aroma perception of red wine? Demonstration by dynamic sensory profile evaluation.
Food Chem. 194 , 196-200, (2015) Our study focused on variations in wine aroma perception and molecular composition during tasting over a period of 30min. In parallel, dynamic analytical and sensory methods were applied to study chan... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| (2R,3S)-rel-2,3-Dimercaptosuccinic acid |
| meso-2,3-diisopropyl-succinic acid |
| 2,3-Disulfanylsuccinic acid |
| 3-dimercaptosuccinic acid |
| meso-2,3-Dimercaptosuccinic acid |
| meso-2,3-dimercapto succinic acid |
| Dimercaptosuccinic acid |
| meso-dimercaptosuccinic acid |
| 2,3-disulfanylbutanedioic acid |
| EINECS 206-155-2 |
| MFCD00064799 |
| meso-2,3-Diisopropyl-bernsteinsaeure |
| Succimer |
| 2,3-DIISOPROPYLSUCCINIC ACID |
| 2,3-Dithio-meso-tartaric acid |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What English synonyms does succimer have? |
| A: English synonyms of succimer: (2R,3S)-rel-2,3-Dimercaptosuccinic acid, meso-2,3-diisopropyl-succinic acid, 2,3-Disulfanylsuccinic acid, 3-dimercaptosuccinic acid, meso-2,3-Dimercaptosuccinic acid, meso-2,3-dimercapto succinic acid, Dimercaptosuccinic acid, meso-dimercaptosuccinic acid, 2,3-disulfanylbutanedioic acid, EINECS 206-155-2, MFCD00064799, meso-2,3-Diisopropyl-bernsteinsaeure, Succimer, 2,3-DIISOPROPYLSUCCINIC ACID, 2,3-Dithio-meso-tartaric acid. |
| Q: What is the safety information for succimer? |
| A: Safety information for succimer: 24/25-26-36. |
| Q: What is the molecular weight of succimer? |
| A: Molecular weight of succimer is 182.218. |
| Q: What is the polar surface area (PSA) of succimer? |
| A: Polar surface area (PSA) of succimer is 152.20000. |
| Q: What is the melting point of succimer? |
| A: Melting point of succimer is 196-198ºC (dec.). |
| Q: What is the InChIKey of succimer? |
| A: InChIKey of succimer is ACTRVOBWPAIOHC-XIXRPRMCSA-N. |
| Q: What is the SMILES notation of succimer? |
| A: SMILES notation of succimer is O=C(O)C(S)C(S)C(=O)O. |
| Q: What is the LogP of succimer? |
| A: LogP of succimer is 1.93. |
| Q: What is the English name of succimer? |
| A: The English name of succimer is succimer. |
| Q: What is the CAS number of succimer? |
| A: CAS number of succimer is 304-55-2. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |
| Henan Tianfu Chemical Co., Ltd. |