Etamivan

Modify Date: 2024-01-08 07:20:59

Etamivan Structure
Etamivan structure
Common Name Etamivan
CAS Number 304-84-7 Molecular Weight 223.26800
Density 1.115g/cm3 Boiling Point 401.4ºC at 760mmHg
Molecular Formula C12H17NO3 Melting Point 96-97ºC
MSDS Chinese USA Flash Point 196.6ºC
Symbol GHS06
GHS06
Signal Word Danger

 Use of Etamivan


Etamivan is a respiratory stimulant drug, mainly used in the treatment of barbiturate overdose and chronic obstructive pulmonary disease.

 Names

Name N,N-diethyl-4-hydroxy-3-methoxybenzamide
Synonym More Synonyms

 Etamivan Biological Activity

Description Etamivan is a respiratory stimulant drug, mainly used in the treatment of barbiturate overdose and chronic obstructive pulmonary disease.
Related Catalog

 Chemical & Physical Properties

Density 1.115g/cm3
Boiling Point 401.4ºC at 760mmHg
Melting Point 96-97ºC
Molecular Formula C12H17NO3
Molecular Weight 223.26800
Flash Point 196.6ºC
Exact Mass 223.12100
PSA 49.77000
LogP 1.88280
Index of Refraction 1.536
Storage condition 2-8℃
Water Solubility methanol: 0.1 g/mL, clear

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YW5250000
CHEMICAL NAME :
Vanillamide, N,N-diethyl-
CAS REGISTRY NUMBER :
304-84-7
BEILSTEIN REFERENCE NO. :
2694478
LAST UPDATED :
199612
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C12-H17-N-O3
MOLECULAR WEIGHT :
223.30
WISWESSER LINE NOTATION :
2N2&VR DQ CO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
154 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 17,41,1959
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
28 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV. Volume(issue)/page/year: 243,609,1956
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
17 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.) V.1-41, 1958-82. For publisher information, see BBIADT. Volume(issue)/page/year: 9,67,1962
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
67 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - rigidity (including catalepsy)
REFERENCE :
RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 1,423,1964
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
38 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - rigidity (including catalepsy)
REFERENCE :
RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 1,423,1964
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
57 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - rigidity (including catalepsy)
REFERENCE :
RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 1,423,1964
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
15 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,377,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,377,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
30 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,377,1972

 Safety Information

Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301
Precautionary Statements P301 + P310
Personal Protective Equipment Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes T: Toxic;
Risk Phrases 25
Safety Phrases 36/37/39-45
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS YW5250000
Packaging Group III
Hazard Class 6.1(b)
HS Code 2924299090

 Synthetic Route

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Etamivan Structure

Etamivan

CAS#:304-84-7

Literature: DE839938 , ; DRP/DRBP Org.Chem.

 Precursor & DownStream

Precursor  2

DownStream  0

 Customs

HS Code 2924299090
Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Articles11

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Pentylenetetrazol and ethamivan effects on brain serotonin metabolism.

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Prog. Neuropsychopharmacol. 4(4-5) , 469-89, (1980)

 Synonyms

N,N-Diethylvanillamide
ETHAMIVAN
Diethamivan
Simaron
N,N-DIETHYLVANILLAMIDE
N,N-diethyl-3-methoxy-4-hydroxybenzamide
4-hydroxy-3-methoxydiethylbenzamide
Corivanil
Vanillic acid diethylamide
vanillic acid N,N-diethyl amide
Ethamivan N,N-Diethyl-4-hydroxy-3-methoxybenzamide N,N-Diethylvanillamide
Etamivan
N,N-diethyl-4-hydroxy-3-methoxy-benzamide
Cardiovanil
Cardiovamil
Analepticon
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Etamivan suppliers


Price: $79/10mM*1mLinDMSO

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