Ethapon

Modify Date: 2024-01-04 18:25:01

Ethapon structure	Common Name	Ethapon
	CAS Number	115-20-8	Molecular Weight	149.404
	Density	1.6±0.1 g/cm3	Boiling Point	152.1±35.0 °C at 760 mmHg
	Molecular Formula	C₂H₃Cl₃O	Melting Point	17.8 °C(lit.)
	MSDS	Chinese USA	Flash Point	45.8±25.9 °C
	Symbol	GHS05, GHS07	Signal Word	Danger

Use of Ethapon

2,2,2-Trichloroethanol, the active form of the sedative hypnotic drug chloral hydrate, is an agonist for the nonclassical K2P channels TREK-1 (KCNK2) and TRAAK (KCNK4)[1].

Name	2,2,2-trichloroethanol
Synonym	More Synonyms

Description	2,2,2-Trichloroethanol, the active form of the sedative hypnotic drug chloral hydrate, is an agonist for the nonclassical K2P channels TREK-1 (KCNK2) and TRAAK (KCNK4)[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
In Vitro	2,2,2-trichloroethanol activates a nonclassical potassium channel in cerebrovascular smooth muscle and dilates the middle cerebral artery[1].
References	[1]. Nikhil K Parelkar , et al. 2,2,2-trichloroethanol Activates a Nonclassical Potassium Channel in Cerebrovascular Smooth Muscle and Dilates the Middle Cerebral Artery. J Pharmacol Exp Ther. 2010 Mar;332(3):803-10.

Density	1.6±0.1 g/cm3
Boiling Point	152.1±35.0 °C at 760 mmHg
Melting Point	17.8 °C(lit.)
Molecular Formula	C₂H₃Cl₃O
Molecular Weight	149.404
Flash Point	45.8±25.9 °C
Exact Mass	147.924942
PSA	20.23000
LogP	1.38
Vapour density	5.16 (vs air)
Vapour Pressure	1.3±0.6 mmHg at 25°C
Index of Refraction	1.499

Ethapon MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KM3850000

CHEMICAL NAME :: Ethanol, 2,2,2-trichloro-

CAS REGISTRY NUMBER :: 115-20-8

BEILSTEIN REFERENCE NO. :: 1697495

LAST UPDATED :: 199710

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C2-H3-Cl3-O

MOLECULAR WEIGHT :: 149.40

WISWESSER LINE NOTATION :: Q1XGGG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory depression Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory depression Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Behavioral - sleep

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Rectal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory depression Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4200 mg/kg/14D-I

TOXIC EFFECTS :: Blood - changes in other cell count (unspecified) Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - changes in calcium

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 14400 mg/kg/90D-I

TOXIC EFFECTS :: Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - changes in calcium Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 178 gm/L

REFERENCE :: TOERD9 Toxicological European Research. (S.P.E., 10, Ave. de Messine, 75008 Paris, France) V.1- 1978- Volume(issue)/page/year: 3,63,1981

Symbol	GHS05, GHS07
Signal Word	Danger
Hazard Statements	H302-H318-H336
Precautionary Statements	P261-P280-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xn:Harmful;
Risk Phrases	R22;R41
Safety Phrases	S26-S39
RIDADR	1760
WGK Germany	1
RTECS	KM3850000
Packaging Group	III
HS Code	29055910

Precursor 10
CAS#:515-84-4 Ethyl trichloro... CAS#:302-17-0 Chloral hydrate CAS#:75-87-6 Chloral CAS#:41262-38-8 trimethyl(2,2,2...
CAS#:86379-25-1 tert-butyldimet... CAS#:76-02-8 Trichloroacetyl... CAS#:76-03-9 Trichloroacetic acid CAS#:50-00-0 Formaldehyde
CAS#:67-66-3 Chloroform CAS#:108-93-0 Cyclohexanol
DownStream 10
CAS#:1118-44-1 2,2,2-trichloro... CAS#:107-69-7 2,2,2-Trichloro... CAS#:451-40-1 2-Phenylacetophenone CAS#:101-81-5 Diphenylmethane
CAS#:632-50-8 Benzene,1,1',1'... CAS#:143330-91-0 2,2,2-Trichloro... CAS#:44925-09-9 2,2,2-Trichloro... CAS#:20405-30-5 tris(2,2,2-tric...
CAS#:82564-87-2 diethyl 2,2,2-t... CAS#:123-54-6 2,4-Pentandione

HS Code	2905590090
Summary	2905590090 other halogenated, sulphonated, nitrated or nitrosated derivatives of acyclic alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Validation of a general method for activity estimation of cyanide evolving oxidoreductases.

Anal. Biochem. 471 , 44-50, (2015)

Ethylene is a key molecule in organic synthesis currently produced by steam cracking of fossil hydrocarbons. In nature, ethylene is produced in higher plants by 1-aminocyclopropane-1-carboxylic acid o...

Trichloroethylene and trichloroethanol-induced formic aciduria and renal injury in male F-344 rats following 12 weeks exposure.

Toxicology 323 , 70-7, (2014)

Trichloroethylene (TCE) is widely used as a cleaning and decreasing agent and has been shown to cause liver tumours in rodents and a small incidence of renal tubule tumours in male rats. The basis for...

Interaction proteomics of canonical Caspr2 (CNTNAP2) reveals the presence of two Caspr2 isoforms with overlapping interactomes.

Biochim. Biophys. Acta 1854 , 827-33, (2015)

Autism is a human developmental brain disorder characterized by impaired social interaction and communication. Contactin-associated protein-like 2 (Caspr2, CNTNAP2) is a known genetic risk factor of a...

Ethanol, 2,2,2-trichloro-

2,2,2-Trichloroethanol

Trichloroethyl alcohol

EINECS 204-071-0

MFCD00004677

Trichloroethanol

Ethapon

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Ethapon
Price: ￥178.0/100g ￥618.0/500g
Purity: 98.0%
Stocking Period: Inquiry
Contact: Liu jia

DC Chemicals Limited
China
Product Name: 2,2,2-Trichloroethanol
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2,2,2-Trichloroethanol
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Trichloroethanol 99.0%
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Ethapon

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Ethapon Biological Activity

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