(20S)-Protopanaxdiol

Modify Date: 2024-01-03 08:45:00

(20S)-Protopanaxdiol structure	Common Name	(20S)-Protopanaxdiol
	CAS Number	30636-90-9	Molecular Weight	460.732
	Density	1.0±0.1 g/cm3	Boiling Point	559.5±40.0 °C at 760 mmHg
	Molecular Formula	C₃₀H₅₂O₃	Melting Point	211 °C
	MSDS	N/A	Flash Point	226.1±21.9 °C

Use of (20S)-Protopanaxdiol

(20S)-Protopanaxadiol (20-Epiprotopanaxadiol) is an aglycon metabolic derivative of the protopanaxadiol-type ginseng saponin; apoptosis inducer.IC50 value:Target: apoptosis inducer(20S)-Protopanaxadiol was used to induce cytotoxicity for two human glioma cell lines, SF188 and U87MG. For the SF188 cells, (20S)-Protopanaxadiol activated caspases-3, -8, -7, and -9 within 3 h and induced rapid apoptosis, which could be partially inhibited by a general caspase blocker and completely abolished when the caspase blocker was used in combination with an antioxidant. (20S)-Protopanaxadiol also induced cell death in U87MG cells but did not activate any caspases in these cells [1]. aPPD was able to inhibit P-gp activity as potently as verapamil on MDR cells. The blockage of P-gp activity was highly reversible as wash-out of aPPD resulted in an immediate recovery of P-gp activity. Unlike verapamil, aPPD did not affect ATPase activity of P-gp suggesting a different mechanism of action [2].

Name	(20S)-protopanaxadiol
Synonym	More Synonyms

Description	(20S)-Protopanaxadiol (20-Epiprotopanaxadiol) is an aglycon metabolic derivative of the protopanaxadiol-type ginseng saponin; apoptosis inducer.IC50 value:Target: apoptosis inducer(20S)-Protopanaxadiol was used to induce cytotoxicity for two human glioma cell lines, SF188 and U87MG. For the SF188 cells, (20S)-Protopanaxadiol activated caspases-3, -8, -7, and -9 within 3 h and induced rapid apoptosis, which could be partially inhibited by a general caspase blocker and completely abolished when the caspase blocker was used in combination with an antioxidant. (20S)-Protopanaxadiol also induced cell death in U87MG cells but did not activate any caspases in these cells [1]. aPPD was able to inhibit P-gp activity as potently as verapamil on MDR cells. The blockage of P-gp activity was highly reversible as wash-out of aPPD resulted in an immediate recovery of P-gp activity. Unlike verapamil, aPPD did not affect ATPase activity of P-gp suggesting a different mechanism of action [2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> P-glycoprotein Natural Products >> Steroids Research Areas >> Cancer
References	[1]. Liu GY, et al. 20S-protopanaxadiol-induced programmed cell death in glioma cells through caspase-dependent and -independent pathways. J Nat Prod. 2007 Feb;70(2):259-64. [2]. Zhao Y, et al. 20S-protopanaxadiol inhibits P-glycoprotein in multidrug resistant cancer cells. Planta Med. 2009 Aug;75(10):1124-8.

Description

Related Catalog

Signaling Pathways >> Membrane Transporter/Ion Channel >> P-glycoprotein

Natural Products >> Steroids

Research Areas >> Cancer

References

[1]. Liu GY, et al. 20S-protopanaxadiol-induced programmed cell death in glioma cells through caspase-dependent and -independent pathways. J Nat Prod. 2007 Feb;70(2):259-64.

[2]. Zhao Y, et al. 20S-protopanaxadiol inhibits P-glycoprotein in multidrug resistant cancer cells. Planta Med. 2009 Aug;75(10):1124-8.

Density	1.0±0.1 g/cm3
Boiling Point	559.5±40.0 °C at 760 mmHg
Melting Point	211 °C
Molecular Formula	C₃₀H₅₂O₃
Molecular Weight	460.732
Flash Point	226.1±21.9 °C
Exact Mass	460.391632
PSA	60.69000
LogP	7.59
Vapour Pressure	0.0±3.5 mmHg at 25°C
Index of Refraction	1.529

Hazard Codes	Xi

Protopanaxadiol

Protopanaxtriol

(20S)-Protopanaxadiol

20(S)-Protopanaxdiol

(3β,12β)-Dammar-24-ene-3,12,20-triol

PROTOPANAXDIOL

Dammar-24-ene-3,12,20-triol, (3β,12β)-

Protopanaxadiol, 20S-

BioBioPha
China
Product Name: (20S)-Protopanaxdiol
Price: ￥Inquiry/50mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: (20S)-Protopanaxdiol
Price: ￥298.0/20mg
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: (20S)-Protopanaxadiol
Price: $350.0/100mg $650.0/250mg $1300.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Protopanaxdiol
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: PROTOPANAXDIOL
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

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Price: $97/10mM*1mLinDMSO

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(20S)-Protopanaxdiol

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