5-Methyl-4-phenyl-1,3-thiazol-2-amine

Modify Date: 2025-08-25 12:14:05

5-Methyl-4-phenyl-1,3-thiazol-2-amine Structure
5-Methyl-4-phenyl-1,3-thiazol-2-amine structure
Common Name 5-Methyl-4-phenyl-1,3-thiazol-2-amine
CAS Number 30709-67-2 Molecular Weight 190.265
Density 1.2±0.1 g/cm3 Boiling Point 349.7±11.0 °C at 760 mmHg
Molecular Formula C10H10N2S Melting Point 122-126ºC
MSDS Chinese USA Flash Point 165.3±19.3 °C
Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger

 Names

Name 5-methyl-4-phenyl-1,3-thiazol-2-amine
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 349.7±11.0 °C at 760 mmHg
Melting Point 122-126ºC
Molecular Formula C10H10N2S
Molecular Weight 190.265
Flash Point 165.3±19.3 °C
Exact Mass 190.056473
PSA 67.15000
LogP 2.60
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.643
InChIKey HTXQOROHFFYFMC-UHFFFAOYSA-N
SMILES Cc1sc(N)nc1-c1ccccc1

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XJ2650000
CHEMICAL NAME :
Thiazole, 2-amino-5-methyl-4-phenyl-
CAS REGISTRY NUMBER :
30709-67-2
BEILSTEIN REFERENCE NO. :
0137628
LAST UPDATED :
199706
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C10-H10-N2-S
MOLECULAR WEIGHT :
190.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
71 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APSXAS Acta Pharmaceutica Suecica. (Apotekarsocieteten-Farmacevtiska Foereningen, Box 1136, S-111, 81 Stockholm, Sweden) V.1- 1964- Volume(issue)/page/year: 8,49,1971

 Safety Information

Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger
Hazard Statements H302-H315-H318-H335
Precautionary Statements P261-P280-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn,Xi
Risk Phrases R22
Safety Phrases 26-36/37/39
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS XJ2650000
HS Code 2934100090

 Synthetic Route

 Customs

HS Code 2934100090
Summary 2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

 5-Methyl-4-phenyl-1,3-thiazol-2-amineBioassay

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Name: Primary cell-based high-throughput screening assay for identification of compounds th...
Source: Johns Hopkins Ion Channel Center
Target: regulator of G-protein signaling 4 isoform 2 [Homo sapiens]
External Id: JHICC_RGS_Act_HTS
Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
Name: QFRET-based biochemical primary high throughput screening assay to identify exosite i...
Source: The Scripps Research Institute Molecular Screening Center
Target: disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id: ADAM17_INH_QFRET_1536_1X%INH PRUN
Name: Binding affinity to oxidoreductase 1 (unknown origin) at 200 uM by surface plasmon re...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3414328
Name: Binding affinity to Plasmodium falciparum AMA1 at 200 uM by surface plasmon resonance...
Source: ChEMBL
Target: Apical membrane antigen 1
External Id: CHEMBL3414329
Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
Name: uHTS identification of small molecule activators of the adaptive arm of the Unfolded ...
Source: Burnham Center for Chemical Genomics
Target: N/A
External Id: BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay
Name: Binding affinity to oxidoreductase 2 (unknown origin) at 200 uM by surface plasmon re...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3414327
Name: Binding affinity to protein kinase (unknown origin) at 200 uM by surface plasmon reso...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3414332
Name: Binding affinity to SPSB2 (unknown origin) at 200 uM by surface plasmon resonance met...
Source: ChEMBL
Target: SPRY domain-containing SOCS box protein 2
External Id: CHEMBL3414330
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 Synonyms

5-Methyl-4-phenyl-thiazol-2-ylamin
MFCD00617257
2-amino-4-phenyl-5-methylthiazole
5-Methyl-4-phenyl-1,3-thiazol-2-amine
2-amino-5-methyl-4-phenylthiazole
5-methyl-4-phenylthiazol-2-amine
5-Methyl-4-phenylthiazol-2-amine hydrobromide
Thiazole,2-amino-5-methyl-4-phenyl
5-Methyl-4-phenyl-2-thiazolamine
2-Thiazolamine,5-methyl-4-phenyl
5-methyl-4-phenyl-1,3-thiazole-2-amine
5-Methyl-4-phenyl-thiazol-2-ylamine
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