LMP744 hydrochloride

Modify Date: 2024-01-02 17:43:32

LMP744 hydrochloride structure	Common Name	LMP744 hydrochloride
	CAS Number	308246-57-3	Molecular Weight	488.91800
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₂₅ClN₂O₇	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of LMP744 hydrochloride

LMP744 hydrochloride (MJ-III65 hydrochloride) is a DNA intercalator and Topoisomerase (Top1) inhibitor with antitumor activity[1].

Name	6-[3-[(2-Hydroxyethyl)amino]propyl]-5,11-diketo-2,3-dimethoxy-8,9-(methylenedioxy)-11H-indeno[1,2-c]isoquinoline Hydrochloride
Synonym	More Synonyms

Description	LMP744 hydrochloride (MJ-III65 hydrochloride) is a DNA intercalator and Topoisomerase (Top1) inhibitor with antitumor activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
Target	Top1[1].
In Vitro	The GI50 value of LMP744 (MJ-III-65) for NCI60 cells is 0.1 μM[1]. LMP744 (0.1-5 μM, 3 days) induces dose-dependent accumulation of cells in the S and G2 phases of the cell cycle[1]. Cell Cytotoxicity Assay[1] Cell Line: P388 and P388 Top1-deficient murine leukemia cells Concentration: 0.1-100 μM Incubation Time: 3 days Result: induced dose-dependent accumulation of cells in the S and G2 phases of the cell cycle
In Vivo	MJ-III-65 (10-50 mg/kg) administered i.v. push once a week for 4 weeks in nude mice moderately actives against human A253 and FaDu tumor xenografts without significant toxicity[2]. Animal Model: Athymic nude mice (nu/nu, female, 20-25 g, 8-12 weeks old) transplanted with A253 and FaDu human head and neck xenografts[2]. Dosage: 10, 25, or 50 mg/kg/week, 4 weeks Administration: i.v. push via tail vein Result: moderately actived against human A253 and FaDu tumor xenografts without significant toxicity
References	[1]. Antony S, et al. Bisindenoisoquinoline bis-1,3-{( 5,6-dihydro-5,11-diketo-11H-indeno [1,2-c]isoquinoline)-6-propylamino}propane bis(trifluoroacetate) (NSC 727357), a DNA intercalator and topoisomerase inhibitor with antitumor activity. Mol Pharmacol. 2006 Sep;70(3):1109-20. [2]. Antony S, et al. Cellular topoisomerase I inhibition and antiproliferative activity by MJ-III-65 (NSC 706744), an indenoisoquinoline topoisomerase I poison. Mol Pharmacol. 2005 Feb;67(2):523-30.

Molecular Formula	C₂₄H₂₅ClN₂O₇
Molecular Weight	488.91800
Exact Mass	488.13500
PSA	108.25000
LogP	3.12370
Storage condition	2-8℃

5H-[1,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione,6-[3-[(2-hydroxyethyl)amino]propyl]-2,3-dimethoxy-,monohydrochloride

DC Chemicals Limited
China
Product Name: LMP744
Price: $900.0/100mg $1700.0/250mg $3200.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Price: ￥14400/1 mg

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LMP744 hydrochloride

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